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Protocol Recommendations for Use of …

Protocol Recommendations FOR. USE OF METHOTREXATE AND. MISOPROSTOL IN EARLY ABORTION. INTRODUCTION: Both methotrexate and misoprostol have been approved by the Food and Drug Administration (FDA) for purposes unrelated to abortion. Administration of methotrexate and misoprostol for induction of abortion in very early pregnancy has been reported in the medical literature, and the scientific evidence indicates that it is safe and efficacious for this use. Clinicians can prescribe methotrexate and misoprostol at their discretion for this off-label use. These Protocol Recommendations were initially developed at a meeting convened by the National Abortion Federation (NAF) and Planned Parenthood Federation of America (PPFA) on June 6, 1996.

NAF Methotrexate/Misoprostol Recommendations/Page 4 of 7 b. If patient is at high risk of possible ectopic pregnancy, measure quantitative -hCG: 1) -hCG >2,000 IU/L: pregnancy is very likely an ectopic pregnancy and patient

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