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Quantitative Genetics - WOU

Quantitative Genetics Polygenic inheritanceContinuous variation Additive alleles Calculating the number of genes HeritabilityStatistical tools: Mean, variance Broad sense heritability Narrow sense heritability Correlation: Twin Studies and concordance Polygenic inheritance 2 or more genes Show continuous variation vsdiscontinuous Additive component Distinct phenotypic classes Quantitative traits: size, weight, height,IQPolygenic inheritanceContinuous variation Kolreuter scross Dwarf x tall tobacco F1 intermediate F2 intermediate, normal distributionMultiple gene hypothesis East s cross of Nicotianawith different corolla length Indicates Mendeliansegregation of different phenotypic classes Took subsets of F2and factor hypothesis Characters quantified Two or more genes Additive alleles Contribute a constant amount Non-additive add nothing All alleles add equallyCalculation of number of genes (1/4)n= ratio of f2 individuals showing extreme phenotype n = (2n +1) phenotypic classesStatistical Analysis Mean (X) = Xi/n Variance (s2) = ( Xi X)2/n-1 Standard deviation (s) = s2 Heritabilty Genetic contribution to phenotypic variability Broad-sense Heritabilty(H2) Narrow-s

variation vs discontinuous • Additive component • Distinct phenotypic classes • Quantitative traits: size, weight, height,IQ. Polygenic inheritance. Continuous variation • Kolreuter’s cross • Dwarf x tall tobacco • F1 intermediate • F2 intermediate, normal distribution.

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