Reduce friability and improve tablet performance …

Issue 20: SEP 2010 Reduce friability and improve tablet performance during stability studies with a combination of Fujicalin and Neusilin Greetings! Making high quality tablets of acetaminophen can be a big challenge due to its high cohesive property. during mixing, acetaminophen tends to segregate easily causing problems of low content uniformity. Choosing an excipient which has high flowability, high compressibility, high tablet hardness, low friability with appropriate bulk density is an efficient strategy to solve the problem. Fujicalin a directly compressible (DC) excipient which meets all above requirements is one of good choice for formulators in comparison with other DC excipients such as lactose which has poor flowability or mannitol which gives high tablet hardness but high friability . In this newsletter, we introduce a new study by Asai et al. 2009 where Fujicalin and Neusilin in combination Reduce friability and maintain tablet hardness during accelerated stability tests of tablets with 30% of acetaminophen.

Issue 20: SEP 2010 Reduce friability and improve tablet performance during stability studies with a combination of Fujicalin® and Neusilin®

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