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HPLC method development for the simultaneous …
*Correspondence: S. Alt n z. Hacettepe University, Faculty of Pharmacy, Department of Analytical Chemistry. 06100 - Ankara- TURKEY. E-mail: Journal of Pharmaceutical Sciencesvol. 46, n. 4, , 2010 HPLC method development for the simultaneous analysis of amlodipine and valsartan in combined dosage forms and in vitro dissolution studiesMustafa elebier1, Mustafa Sinan Kaynak2,3, Sacide Alt n z1,*, Selma Sahin21 Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey, 2 Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey, 3 Department of Pharmaceutical Technology, Faculty of Pharmacy, In n University, Malatya, TurkeyA simple, rapid and reproducible HPLC method was developed for the simultaneous determination of amlodipine and valsartan in their combined dosage forms, and for drug dissolution studies. A C18 column (ODS 2, 10 m, 200 x mm) and a mobile phase of phosphate buffer (pH , mol L-1):acetonitrile: methanol (46:44:10 v/v/v) mixture were used for separation and quantification.
HPLC method development for the simultaneous analysis of amlodipine and valsartan 763 Array Detector (Waters, USA). A C18 column (Waters Spherisorp (PSS832514) ODS 2, 10 µm, 200 x 4.6 mm;
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