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RP-HPLC method development and validation for …

*Correspondence: S. Alt n z. Hacettepe University, Faculty of Phar-macy, Department of Analytical Chemistry. 06100 - Ankara- Turkey. E-mail: Journal of Pharmaceutical Sciencesvol. 49, n. 2, , 2013RP-HPLC method development and validation for estimation of rivaroxaban in pharmaceutical dosage formsMustafa elebier, Tuba Re ber, Engin Ko ak, Sacide Alt n z*Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, TurkeyRivaroxaban, an anti-clotting medication, acts at a crucial point in the blood-clotting process and stops the formation of blood clots. In this study, RP-HPLC method was developed for the determination of rivaroxaban in tablets (Xarelto (10 mg)). Phenomenex Luna 5 m C18 100 LC Column (250 x mm) was used at 40 oC. Isocratic elution was performed with ACN:Water (55:45 v/v) mixture. The flow rate was mL min-1 and UV detection was at 249 nm.

RPHPLC method development and validation for estimation of rivaroxaban in pharmaceutical dosage forms 361 to 1000 µL by adding water. The concentration of RIV

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  Development, Methods, Validation, Method development

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