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Ruolo dell’acido valproico nel trattamento del …
110 Farmacoterapia e farmacologia clinica Pharmacotherapy and clinical pharmacologyRuolo dell acido valproico nel trattamento del disturbo bipolareRole of valproic acid in the treatment of bipolar disorderN. Mosti, G. PerugiDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universit di PisaSummaryIntroductionBipolar Disorder is a chronic-relapsing syndrome, defined by the occurrence of psycho-affective excitement episodes (mania, hy-pomania), often but not necessarily alternating with periods of depressive inhibition. This condition may determine an heavy quality of life impairment and can lead to the development of progressive disability. A large amount of data suggests the useful-ness of Valproate both in treatment of acute manic episodes and in the prevention of affective aim of the present literature review is upgrade the level of knowledge regarding efficacy and tolerability of Valproic Acid in the acute and long-term treatment of Bipolar extensive examination of international literature was con-ducted on MEDLINE (Pubmed), PsychInfo and Scopus by using the following keywords: bipolar disorder AND val
110 Farmacoterapia e farmacologia clinica • Pharmacotherapy and clinical pharmacology Ruolo dell’acido valproico nel trattamento del disturbo bipolare Role of valproic acid in the treatment of bipolar disorder
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