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SARS-CoV-2 Omicron spike mediated immune escape ...

SARS-CoV-2 Omicron spike mediated immune escape , infectivity and cell-cell fusion Bo Meng1,2, Isabella Ferreira1,2, Adam Abdullahi1,2, Steven A. Kemp1,2, Niluka Goonawardane 1,2, Guido Papa3, Saman Fatihi4, Oscar J. Charles5, Dami Collier1,2, CITIID-NIHR BioResource COVID-19 Collaboration, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Jinwook Choi6, Joo Hyeon Lee6,7, Petra Mlcochova1,2, Leo James3, Rainer Doffinger2, Lipika Thukral4, Kei Sato8,9*, Ravindra K Gupta1,2,10* 1 Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge, UK. 2 Department of Medicine, University of Cambridge, Cambridge, UK.

exposed populations and/or increased replication. Data on replication are limited however. Delta spike was previously shown to confer more efficient cell-cell fusion kinetics compared to Wuhan-12, and syncytia formation has previously been associated with pathogenesis3. Moreover, changes in the PBCS have been associated with pathogenicity.

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