Transcription of Section Editor: Franklin Dexter E STATISTICAL …
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Economics, Education, and Policy Section Editor: Franklin Dexter E STATISTICAL GRAND ROUNDS. Understanding the Mechanism: Mediation Analysis in Randomized and Nonrandomized Studies Edward J. Mascha, PhD,* Jarrod E. Dalton, PhD,* Andrea Kurz, MD, and Leif Saager, Dr med . In comparative clinical studies, a common goal is to assess whether an exposure, or inter- vention, affects the outcome of interest. However, just as important is to understand the mechanism(s) for how the intervention affects outcome. For example, if preoperative anemia was shown to increase the risk of postoperative complications by 15%, it would be important to quantify how much of that effect was due to patients receiving intraoperative transfusions.
982 www.anesthesia-analgesia.org ANESTHESIA & ANALGESIA E STATISTICAL GRAND ROUNDS Acute Versus Chronic Exposures In mediation analysis, it is helpful to distinguish exposures
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