Transcription of Section VIII-E: Viral Agents
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Section VIII-E: Viral Agents
200 Biosafety in Microbiological and Biomedical LaboratoriesSection viii -E: Viral AgentsHantavirusesHantaviruses are negative sense RNA viruses belonging to the genus Hantavirus within the family Bunyaviridae. The natural hosts of hantaviruses are rodent species and they occur worldwide. Hantavirus pulmonary syndrome (HPS) is a severe disease caused by hantaviruses such as Sin Nombre virus or Andes virus whose hosts are rodents in the subfamily Sigmodontinae. This subfamily only occurs in the New World, so HPS is not seen outside North and South America. Hantaviruses in Europe and Asia frequently cause kidney disease, called nephropathica epidemica in Europe, and hemorrhagic fever with renal syndrome (HFRS) in InfectionsDocumented laboratory-acquired infections have occurred in individuals working with Extreme caution must be used in performing any laboratory operation that may create aerosols (centrifugation, vortex-mixing, etc.). Operations involving rats, voles, and other laboratory rodents, should be conducted with special caution because of the extreme hazard of aerosol infection, especially from infected rodent Modes of InfectionHPS is a severe, often fatal disease that is caused by Sin Nombre and Andes or related ,6 Most cases of human illness have resulted from exposures to naturally infected wild rodents or to their excreta.
200 Biosafety in Microbiological and Biomedical Laboratories Section VIII-E: Viral Agents Hantaviruses Hantaviruses are negative sense RNA viruses belonging to …
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