Transcription of Solid Oral Dosage Forms Powder Blending - IKEV
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Solid Oral Dosage Forms Powder Blending - IKEV
Scott Bozzone, OperationsCork, IrelandSolid oral Dosage FormsPowder Blending KEV Meeting May 31, 2001 Mechanisms of Powder Blending Diffusion- redistribution of particles by random motion Vertical or axial motion Seen in rotational blenders Convection- transfer from one location to another Motion imparted by impeller as in Ribbon Blender Shear-formation of slip planes Motion imparted by high intensity mixersClassification of Mixing EquipmentMechanismEquipmentDiffusionV-Bl ender (Twin Shell)(Tumble)Double Cone BlenderBin BlenderHorizontal/Vertical DrumConvectionRibbon(Paddle or Plow)PlanetaryHorizontal High IntensityVertical High IntensityDiffusion (with I-Bar)PneumaticFluid Bed(Expansion with Gas)ReimeltReference: FDA Draft Guidance- SUPAC IR/MR-Scale-Up Post Approval Changes - Immediate and Modified Release - Equipment Addendum, April 1998; Selection vs.
Mechanisms of Powder Blending • Diffusion- redistribution of particles by random motion – Vertical or axial motion – Seen in rotational blenders • Convection- transfer from one location to another – Motion imparted by impeller as in Ribbon Blender
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