Transcription of Summary report on first, second and third generation ...
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Summary report on first, second and third generation ...
Summary report on first, second and third generation smallpox vaccines Content Background .. 3 First generation smallpox vaccines .. 3 second generation vaccines .. 11 third generation vaccines .. 15 Other smallpox vaccines .. 26 Ethical considerations .. 27 References .. 29 The first report was prepared for WHO in August 2013 by H. Meyer, Paul-Ehrlich-Institut and updated in October 2013 following comments received after the expert meeting on smallpox vaccines 2 Abbreviations AE: adverse event CAM: chorioallantois membrane CMI: cell-mediated immunity ECG: electrocardiography ECTV: Ectromelia virus EEV: extracellular enveloped virus GMP: Good manufacturing practice GMT: geometric mean titer IMV: intracellular mature virus MPXV: monkeypox virus NYCBH: New York City Board of Health PFU: pock forming units PRNT: plaque reduction neutralization test pvE: post-vaccinial encephalitis RPXV: rabbitpox virus SCR: seroconversion rate SAE: Serious adverse event WHO: World Health Organisation 3 Background Smallpox has been successfully eradicated by a global effort in the 1960s and 1970s using a panel of live vaccinia virus vaccines.
3 Background Smallpox has been successfully eradicated by a global effort in the 1960s and 1970s using a panel of live vaccinia virus vaccines.
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