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Symptom Management Guidelines: DIARRHEA

Symptom Management Guidelines: CANCER RELATED DIARRHEA Definition Cancer Related DIARRHEA (CRD): An abnormal increase in stool frequency, volume, and liquidity that is different from the usual patterns of bowel elimination; results from cancer or related treatment(s) Contributing Factors Cancer Related Neuroendocrine tumors ( VIPomas, carcinoid, gastrinomas) Lymphoma Graft vs. host disease after bone marrow transplant Cancer Treatment Related Capecitabine 5 fluorouracil Irinotecan Leucovorin Most small molecule oral tyrosine kinase inhibitors Immunotherapy Checkpoint inhibitors ( Ipilimumab) Biotherapy ( high dose Interferon or Interleukin 2) Radiation Therapy Pelvis, abdomen, lumbar, para-aortic fields Surgical History Celiac plexus block Large or small bowel resection Cholecystectomy Pancreaticoduodenectomy (whipple procedure) Vagotomy Terminal ileal resection and lo

Stool Examination Inspect stool for colour (visible blood or mucous), consistency, volume, and odour Skin Integrity Perineal or peristomal skin integrity Note any areas of erythema, edema, exudates, bleeding or skin breakdown Mental Status Confusion, alterations in level of …

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