Transcription of SYSTEMIC LUPUS ERYTH EMATOSUS: PATHOGENESIS, …
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SYSTEMIC LUPUS ERYTH EMATOSUS: PATHOGENESIS, …
Eular On-line Course on Rheumatic Diseases module n 17 Ricard Cervera, Gerard Espinosa, David D Cruz 1 2007-2009 EULAR SYSTEMIC LUPUS ERYTHEMATOSUS: pathogenesis , CLINICAL MANIFESTATIONS AND DIAGNOSIS INTRODUCTION SYSTEMIC LUPUS erythematosus (SLE) is a multisystem autoimmune disorder with a broad spectrum of clinical presentations (1). There is a peak age of onset among young women between the late teens and early 40 s and a female to male ratio of 9:1. Ethnic groups such as those with African or Asian ancestry are more at risk of developing the disorder and it may be more severe compared to Caucasian patients. SLE is a chronic illness that may be life-threatening when major organs are affected but more commonly results in chronic debilitating ill health.
In 1982, Hochberg et al. (12) in England and Wales reported a prevalence of 12.5 cases per 100,000 women of all ages, and was higher at 17.7 in women of 15 to 64 years of age.
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