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The Molecular Basis of Tolerance - National Institutes of ...

The Molecular Basis of Tolerance Andrzej Z. Pietrzykowski, , , and Steven N. Treistman Tolerance is defined as the diminished response to alcohol or other drugs over the course of repeated or prolonged exposure. This mechanism allows physiological processes to achieve stability in a constantly changing environment. The onset of Tolerance may occur within minutes, during a single exposure to alcohol ( , acute Tolerance ), or over longer timeframes and with prolonged exposure to alcohol ( , rapid or chronic Tolerance ). Changes in Tolerance induced by alcohol may affect several processes at the Molecular , cellular, or behavioral level.

The Molecular Basis of Tolerance Andrzej Z. Pietrzykowski, M.D., Ph.D., and Steven N. Treistman Ph.D. Tolerance is defined as the diminished response to alcohol or other drugs over the course of repeated or

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