Transcription of 学位論文の内容の要旨 - tmd.ac.jp
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学位論文の内容の要旨 - tmd.ac.jp
- 1 - Clinicopathological Relevance of Claudin-5 Expression 1 in Breast Cancer < > Claudin Claudin claudin claudin-5 193 claudin-5 (p= ) (p= ) (p= ) estrogen receptor (ER) (p= ) human epidermal growth factor receptor (HER) 2(p= ) claudin-5 (p= ) Kaplan Meier claudin-5 claudin-5 < > 2012 12500 ER, PgR, HER2, ki67 epithelial-mesenchymal transition (EMT) EMT Tight Junction Claudin Tight Junction 1998 Furuse 4 20-27kDa claudin
- 2 - で発現し、臓器や細胞の特異性に関与している。Claudin-5 は血管内皮細胞やリンパ管上皮や子 宮内膜に多く発現し、組織環境の恒常性の維持に重要な役割をしている。
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