学位論文の内容の要旨 - tmd.ac.jp

1 - 1 - Clinicopathological Relevance of Claudin-5 Expression 1 in Breast Cancer < > Claudin Claudin claudin claudin-5 193 claudin-5 (p= ) (p= ) (p= ) estrogen receptor (ER) (p= ) human epidermal growth factor receptor (HER) 2(p= ) claudin-5 (p= ) Kaplan Meier claudin-5 claudin-5 < > 2012 12500 ER, PgR, HER2, ki67 epithelial-mesenchymal transition (EMT)

2 EMT Tight Junction Claudin Tight Junction 1998 Furuse 4 20-27kDa claudin 24 - 2 - Claudin-5 blood-brain barrier Claudin triple negative claudin-low Claudin-3,4,7 occludin E-cadherin claudin Claudin-5 claudin-5 claudin-5 claudin claudin-5 < > 2004 1 2006 12 193 28 92 54 3-6 3 ( )

3 ER PgR HER2 ASCO NCCN - 1+ 1-25% 2+ 26-50% 3+ 51-75% 4+ 76%-100% SPSS ( , SPSS Inc. Chicago, IL, USA) 25% 25% 2 claudin-5 Relapse free survival(RFS) claudin-5 log-rank Kaplan Meier p < < > Claudin-5 (25-100% ) 83 Claudin-5 claudin-5 Claudin-5 (p= ) - 3 - (p= ) ER (p= ) HER2 (p= ) (p= ) (p= ) claudin-5 claudin-5 (p= ) (p= ) (p= ) (p= ) (p= ) claudin-5 (p= ) (hazard ratio, ; 95% confidence interval, ; p= ) claudin-5 (hazard ratio, ; 95% confidence interval.)

4 P= ) 2 ( 2cm or 2cm) triple negative + HER2 positive 4 3 148 45 (p< ) claudin-5 (p= ) < > Claudin-5 claudin claudin-1 claudin-4 Claudin-5 claudin-5 ER HER2 Stage RFS claudin-5 RFS Claudin-5 claudin-2,3,4 matrix metalloproteinases (MMP) claudin-5 MMP2 claudin-5 claudin-5 N-WASP ROCK claudin-5 triple negative + HER2 positive claudin-5 claudin claudin-3,4 Clostridium perfringens enterotoxin (CPE) claudin-3 4 CPE Claudin-5 blood-brain-barrier (BBB)

5 - 4 - < > claudin-5 claudin-5 ( 1 ) 4727 claudin claudin claudin-5 claudin-5 193 claudin-5 4 claudin-5 ER estrogen receptor HER2 claudin-5 Kaplan Meier claudin-5 claudin-5