Transcription of Tolperisone - japi.org
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Tolperisone - japi.org
JAPI FebruAry 2010 VOL. 58 127 Tolperisone , a centrally acting muscle relaxant agent, which has been in therapeutic use for more than three decades, has been widely used as spasmolytics of choice. It is recently launched drug in India for acute and chronic back pain and spasticity of neurological origin. To l p e r i s o n e i s a n a r y l a l k y l - a m i n o k e t o n e h av i n g a n asymmetric carbon atom to the carbonyl group. It has higher muscle relaxant activity than the dextrorotatory enantiomer. It exhibits membrane stabilizing potency, which is characteristic of anti arrythmic and local anesthetic differs from other myotonolytic agents in its pharmacological properties, which mediate muscle relaxation without concomitant sedation1 or withdrawal of actionbeing, centrally acting muscle relaxant, Tolperisone acts at the level of spinal cord by blocking sodium channels and calcium channels.
128 © JAPI • FebruAry 2010 • VOL. 58 safety makes tolperisone a suitable choice of muscle relaxant for a broad range of patients including elderly patients with ...
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