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UKALL 2011 Trial Considerations Rochelle Lowe Clinical ...

UKALL 2011 Trial Considerations Rochelle lowe Clinical Nurse Specialist Preliminary results February 2010 Patients eligible for study 2522 Deaths in induction 25 Non-relapse deaths 82 Relapses 124 Patients randomised 408 high risk, 521 low risk Preliminary results continued High risk 2 years , 3 years , 4 years , 5 years Low risk 2 years 99%, 3 years , 4 & 5 years Other 2 years , 3 years , 4 years , 5 years UKALL 2011 Phase III randomised Trial for patients with Acute Lymphoblastic Leukaemia (ALL) and Lymphoblastic Lymphoma (LBL) aged 1-25 years Recruitment target: 2640 patients Opened 26th April 2012 UKALL 2011 OBJECTIVES To reduce toxicity through introduction of a short 14-day course of high dose dexamethasone in lieu of the conventional lower dose given for 28 days in induction To provide more effective CNS prophylaxis and reduce burden of therapy through introduction of high dose methotrexate and by omission of vincristine and dexamethasone pulses and continuing intrathecal therapy in maintenance To decrease toxicity and reduce burden of therapy by administering a single delayed intensification to all patients and limit

IMPS IN UKALL 2011 Phase of treatment Regime n IMP Formulation Induction A,B,C dexamethasone Tablets or syrup (or injection#) Standard Interim

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