Transcription of WHO Bulletin - World Health Organization
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WHO Bulletin - World Health Organization
The genetics of mental illness: implicationsfor practiceSteven E. Hyman1 Many of the comfortable and relatively simple models of the nature of mental disorders, their causes and their neuralsubstrates now appear quite frayed. Gone is the idea that symptom clusters, course of illness, family history andtreatment response would coalesce in a simple way to yield valid diagnoses. Also too simple was the concept, born ofearly pharmacological successes, that abnormal levels of one or more neurotransmitters would satisfactorily explainthe pathogenesis of depression or schizophrenia. Gone is the notion that there is a single gene that causes any mentaldisorder or determines any behavioural variant. The concept of the causative gene has been replaced by that of geneticcomplexity, in which multiple genes act in concert with non-genetic factors to produce a risk of mental in genetics and neuroscience can be expected to lead to better models that provide improvedrepresentation of the complexity of the brain and behaviour and the development of both.
Bulletin of the World Health Organization, 2000, 78(4) 457. The National Institute of Mental Health, Bethesda, is funding large collaborative projects in China, the Eastern Mediterranean, Europe, Latin America,andtheUSA,aswellasstudiesofisolated populationsintheAzores,Micronesia,theRussian
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