Transcription of WHO Bulletin - World Health Organization
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WHO Bulletin - World Health Organization
The genetics of mental illness: implicationsfor practiceSteven E. Hyman1 Many of the comfortable and relatively simple models of the nature of mental disorders, their causes and their neuralsubstrates now appear quite frayed. Gone is the idea that symptom clusters, course of illness, family history andtreatment response would coalesce in a simple way to yield valid diagnoses. Also too simple was the concept, born ofearly pharmacological successes, that abnormal levels of one or more neurotransmitters would satisfactorily explainthe pathogenesis of depression or schizophrenia.
only become comprehensible in the context of advances at the molecular, cellular and systems levels in neuroscience and the behavioural sciences. Genetics should yield new therapies aimed not just at symptoms but also at pathogenic ... Bulletin of the World Health Organization, 2000, 78(4) # World Health Organization 2000 455 ...
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