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WHO GUIDE

1 Department of Neglected Tropical Diseases Neglected Zoonotic Diseases team(revised 15 June 2010)(revised 15 June 2010) rabies Pre and PostRabies Pre and Post--exposure prophylaxis in Humansexposure prophylaxis in Humans(revised 15 June 2010)(revised 15 June 2010)WHO GUIDEWHO GUIDE forfor2 Department of Neglected Tropical Diseases Neglected Zoonotic Diseases team(revised 15 June 2010)(revised 15 June 2010)General considerationsGeneral considerationsin rabies Postin rabies Post--Exposure prophylaxis (PEP) Exposure prophylaxis (PEP) WHO strongly advocates the use of purified rabies vaccines prepared on cell culture or embryonated eggs for PEP that comply with WHO criteria for potency, innocuity and have been assessed satisfactorily in humans in well-designed field trials;WHO supports the trend to abandon completely the production and use ofbrain-tissue including suckling mouse brain Department of Neglected Tropical Diseases Neglected Zoonotic Diseases team(revised 15 June 2010)(revised 15 June 2010) is an emergency and as a general rule should not be delayed or deferred; does not have contraindications if purified rabies immunoglobulin and vaccine are used; must be applied using vaccine regimens and routes of administration that have been proven to be safe and washing/flushing and disinfection of the wound plus rapidadministration of purified immunoglobulin and vaccineaccording to the mo

1 – Department of Neglected Tropical Diseases – Neglected Zoonotic Diseases team (revised 15 June 2010) Rabies Pre and Post-exposure Prophylaxis

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