Discriminatory Dissolution Method Development and ...
high solubility in gastric media [low pH] and decreasing solubility with increasing pH). The presence of bile salts and lecithin in biorelevant media does not appear to Discriminatory Dissolution Method Development and Validation of Etoricoxib Tablets Yasvanth Ashokraj*, Atul Daroi, Raja Gupta, Aruna Khanolkar,
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dissolutiontech.comfrequently used to improve the solubility of poorly soluble drugs in dissolution; the activity of the enzymes can be affected by the surfactant, especially when an anionic surfactant is involved like sodium lauryl sulfate (SLS). In dissolution experiments with moderately stressed HGCs containing a water-insoluble drug in both simulated