DRUG NAME: Methotrexate
thymidylate synthesis. Folic acid is reduced to tetrahydrofolate by dihydrofolate reductase (DHFR). The cytotoxicity of methotrexate results from three actions: inhibition of DHFR, inhibition of thymidylate, and alteration of the transport of reduced folates.3 Inhibition of DHFR results in a deficiency of thymidylate and purines and therefore a
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