Importance, Objectives & Factors Affecting Dissolution ...
excipient /drug ratio increases from 3:1 to 7:1 to 11:1. 2) DISINTEGRANTS Disintegrating agent added before & after the granulation affects the dissolution rate. Studies of various disintegrating agents on Phenobarbital tablet showed that when copagel (low viscosity grade of Na CMC) added before granulation decreased
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