SAFETY DATA SHEET Page: 1 Loperamide …

1 02/19/2019 Revision:Page: 1 of 5 Loperamide (hydrochloride) SAFETY data SHEET03/27/2014 Supersedes Revision:according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 2015/830 and US OSHA HCS Product Code:Section 1. Identification of the Substance/Mixture and of the Company/UndertakingLoperamide (hydrochloride) Product Name:Cayman Chemical CompanyCompany Name:1180 E. Ellsworth Arbor, MI 48108 CHEMTREC Within USA and Canada:Emergency Contact:+1 (800)424-9300 CHEMTREC Outside USA and Canada:+1 (703)527-3887 Cayman Chemical CompanyInformation:+1 (734)971-3335 For research use only, not for human or veterinary identified site address:4-(4-chlorophenyl)-4-hydroxy-N.

2 ,monohydrochloride; Imodium; NSC 696356; PJ 185; R 18553; Details of the Supplier of the SAFETY data Relevant identified uses of the substance or mixture and uses advised Emergency telephone number:Section 2. Hazards IdentificationAcute Toxicity: Oral, Category Classification of the Substance or Mixture:H301: Toxic if Hazard Label Elements:DangerGHS Signal Word:P264: Wash {hands} thoroughly after Precaution Phrases:P301+310: IF SWALLOWED: Immediately call a POISON CENTER or : Rinse Response Phrases:Please refer to Section 7 for Storage and Section 13 for Disposal Storage and Disposal may be irritating to the mucous membranes and upper respiratory be harmful by inhalation or skin cause eye, skin, or respiratory system if the best of our knowledge, the toxicological properties have not been thoroughly Human HealthEffects and Symptoms:Multi-region format02/19/2019 Revision:Page: 2 of 5 Loperamide (hydrochloride) SAFETY data SHEET03/27/2014 Supersedes Revision:CAS # /RTECS #Hazardous Components (Chemical Name)/REACH Registration 3.

3 Composition/Information on IngredientsConcentrationEC Index Classification 34552-83-5TM4960000 Loperamide (hydrochloride) %252-082-4 NAAcute Tox.(O) 3: H301 Section 4. First Aid MeasuresDescription of First AidMeasures:Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Have eyes examinedand tested by medical Case of Eye Contact:Immediately wash skin with soap and plenty of water for at least 15 minutes. Remove contaminatedclothing. Get medical attention if symptoms occur. Wash clothing before Case of Skin Contact:Wash out mouth with water provided person is conscious. Never give anything by mouth to anunconscious person.

4 Get medical attention. Do NOT induce vomiting unless directed to do so bymedical Case of Ingestion:Remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained immediate medical Case of 5. Fire Fighting MeasuresFlash Pt:No in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH approved orequivalent), and full protective gear to prevent contact with skin and Fighting Instructions:Autoignition Pt:No Limits:LEL: No data . UEL: No alcohol-resistant foam, carbon dioxide, water, or dry chemical water spray to cool fire-exposed ExtinguishingMedia:A solid water stream may be ExtinguishingMedia:No data Properties data 6.

5 Accidental Release MeasuresContain spill and collect, as to a chemical waste container for disposal in accordance with local and Material ForContainment and CleaningUp:Avoid raising and breathing dust, and provide adequate conditions warrant, wear a NIOSH approved self-contained breathing apparatus, or respirator,and appropriate personal protection (rubber boots, SAFETY goggles, and heavy rubber gloves).Protective Precautions,Protective Equipment andEmergency Procedures:Take steps to avoid release into the environment, if safe to do 7. Handling and StorageAvoid breathing dust/fume/gas/mist/ prolonged or repeated To Be Takenin Handling:Keep container tightly in accordance with information listed on the product To Be Takenin Storing:Multi-region format02/19/2019 Revision:Page: 3 of 5 Loperamide (hydrochloride) SAFETY data SHEET03/27/2014 Supersedes Revision:Section 8.

6 Exposure Controls/Personal Exposure approved respirator, as conditions Equipment(Specify Type): SAFETY glassesEye Protection:Compatible chemical-resistant glovesProtective Gloves:Lab coatOther Protective Clothing:Use process enclosures, local exhaust ventilation, or other engineering controls to control airbornelevels below recommended exposure Controls(Ventilation etc.):Do not take storing or utilizing this material should be equipped with an eyewash and a SAFETY thoroughly after Practices:No data Exposure Personal protection equipment:Section 9. Physical and Chemical PropertiesPhysical States:[ ] Gas [ ] Liquid [ X ] SolidMelting Point:No Point:No Pt:No Limits:LEL: No data .

7 UEL: No Pressure (vs. Air or mmHg):No Density (vs. Air = 1):No Rate:No :No crystalline solidAppearance and Information on Basic Physical and Chemical PropertiesFlammability (solid, gas):No data Gravity (Water = 1):No in Water:No data .~ mg/ml in a 1:1 solution of EtOH:PBS (pH ); ~10 mg/ml in EtOH; ~ mg/ml inDMSO Solubility Notes:Octanol/Water PartitionCoefficient:No Temperature:No Pt:No :No format02/19/2019 Revision:Page: 4 of 5 Loperamide (hydrochloride) SAFETY data SHEET03/27/2014 Supersedes Revision:Percent Volatile:No Other InformationMolecular Formula & Weight:C29H33 ClN2 HCl 10.

8 Stability and ReactivityNo data To Avoid:Unstable [ ] Stable [ X ]Stability:strong oxidizing agentsIncompatibility - MaterialsTo Avoid:carbon dioxidecarbon monoxidehydrogen chloride gasnitrogen oxidesHazardousDecomposition orByproducts:Will occur [ ] Will not occur [ X ]Polymerization:Stable if stored in accordance with information listed on the product Note(s):No data #Hazardous Components (Chemical Name)NTPS ection 11. Toxicological InformationThe toxicological effects of this product have not been thoroughly (hydrochloride) - Toxicity data : Oral TDLO (child): 125 g/kg; Oral LD50 (rat): 185mg/kg; Subcutaneous LD50 (rat): 78700 g/kg; Oral LD50 (mouse): 105 mg/kg; IntraperitonealLD50 (mouse): 28 mg/kg; Subcutaneous LD50 (mouse): 75 mg/kg.

9 Information onToxicological Effects: Loperamide (hydrochloride) - Investigated as a drug and reproductive select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented actual entry in RTECS for complete (hydrochloride) RTECS Number: TM4960000 Chronic ToxicologicalEffects:IARCACGIHOSHA 34552-83-5 Loperamide (hydrochloride) release into the from fire control or dilution water may cause :Section 12. Ecological InformationNo data andDegradability:No data :No data in Soil:No data of PBT and data adverse effects:Multi-region format02/19/2019 Revision:Page: 5 of 5 Loperamide (hydrochloride) SAFETY data SHEET03/27/2014 Supersedes in accordance with local, state, and federal Disposal Method:Section 13.

10 Disposal ConsiderationsSection 14. Transport InformationToxic solid, organic, ( Loperamide (hydrochloride))DOT Proper Shipping POISONDOT Hazard Class:UN2811UN/NA Number:IIIP acking LAND TRANSPORT (US DOT):Toxic solid, organic, ( Loperamide (hydrochloride))ADR/RID Shipping LAND TRANSPORT (European ADR/RID):2811UN Number:IIIP acking - POISONH azard Class:Toxic solid, organic, ( Loperamide (hydrochloride))ICAO/IATA Shipping AIR TRANSPORT (ICAO/IATA):2811UN Number:IIIP acking - POISONH azard Classification:Transport in accordance with local, state, and federal sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code ofE1, E2, E4, or E5, this item meets the De Minimis Quantities exemption, per IATA packaging does not have to be labeled as Dangerous Goods/Excepted TransportInformation:CAS #Hazardous Components (Chemical Name)Section 15.