Transcription of Nephron Schematic - Columbia Nephrology
1 Nephron Schematic blo od e Blood Flow phrin Find an error? o r e pine etic) email N pat h (Sym iotensin K Na Ang II. Afferent Arteriole Glucose Amino Acids ATP ANP. Phosphate, ~ 3% of NA. in gland Lactate, or +r Prosta ine ea m citrate bs a or Gl p b & Do uc Na ed Am os rent Arteriole -F. 85% of reabsorbed HCO3- (if CO2 from tubule). e in t. ine Late Distal o secre Ac Na Ph cta e, Tubule &. Tun id JGA. la trat os te, s Renin Collecting Duct in ci ph or Na , -Intercalated &. g Site at e Principal Cells Effe H2O imp. w/o ADH. Early Proximal H2O permeable Tubule with ADH. Isosm. abs. Na be d Early Distal or H. +. 67 b s Tubule +. rea etics k -Intercalated HC. load-depend. %. A + r c +. H of N diu blo H20 imp. Reabsorb K. O3. of - 5% d e Dilutes Na + a i H excretion HCO -3 + H + ~ iaz NaCl abs. Th Aldost. stim'd Na+. H 2 CO 3. H 2 PO 4- excret. nd K+ reabsorbed Cl - NH 4+ excret. New HCO3- (if NH4+ excreted). ic). H 2CO 3 Cl - Furosemide (loop diuret IV (blocked by ace K+.)
2 (HPO4 or ). carbonic anhydrase II AT. P K Na+. CO 2 + H2 O. 2- CO 2+ H2 O. Na ATP. K+. reabsorbed (if not blocked). NH3 + H+. blocks HCO-3 + H+ H+. tazolamide). Late Proximal Tubule ATP. Na + K+. Isosm. absorption New H2CO 3. - Na+ 2 Cl HCO-3 H+. K + absorbed ATP. Na + CO2 + H2O. H. (excreted). K. NH +4. ATP Principal Cell K Cl - ATP. Secrete K +. Na Formate- (or H2 PO4 ). Cl- Add aquaporin2. 25% of Na+ and 20% of K+. +. Na, K+ ADH R. - - Cl H2O. Cl - Gs ATP H2O. Thick K+ AC. (inhibit aldost. effect). K -sparing diuretics ANP also blocks Ascending Limb cAMP. Angiotensin II Stimulated load-depend. PKA. Aldosterone Stimulated H2O imp. Dilutes phosphoryl'n ADH (vasopressin) Stimulated ANP Stimulated Na+. Na Sympathetic (Norepi.) Stimulated ATP. K+. Thin Ascending Limb K. H2O impermeable Vasodilator Vasoconstrictor Aldosterone increases # of: Major effect 1. Na+ channels Minor effect 2. Na+-K +-ATPase pumps insignificant, unless lots o' stim. 3. K + channels
