Induced Hepatotoxicity
Found 6 free book(s)
DRUG NAME: Methotrexate - BC Cancer
www.bccancer.bc.caMethotrexate-induced hepatotoxicity can be seen with both high and low-dose methotrexate, and can be life-threatening. 20. Increased serum aminotransferases (14%) and less commonly hyperbilirubinemia is seen more often in high-dose methotrexate. 8.
BLOOD SCIENCES DEPARTMENT OF CLINICAL BIOCHEMISTRY …
www.nbt.nhs.ukgreater risk from statin-induced hepatotoxicity Consider using a fibrate first line if isolated raised triglycerides 5-10 mmol/l. Refer Lipid Clinic if triglycerides > 10mmol/l. Look for and treat hypertension particularly in patients with type 2 DM. Consider ACE Inhibitors or A2RA’s as first line therapies for hypertensive patients with NAFLD.
EASL Clinical Practice Guidelines: Drug-induced liver injury
easl.euIdiosyncratic hepatotoxicity can be severe, leading to a particularly serious variety of acute liver failure for which no effective therapy has yet been developed. These Clinical Practice Guidelines summarize the available evi-dence on risk factors, diagnosis, management and risk mini-mization strategies for drug-induced liver jury.
DRUG NAME: Ribociclib - BC Cancer
www.bccancer.bc.caHepatotoxicity has also been reported, including hepatocellular injury and drug-induced liver i njury. Monitor liver function tests at baseline and throughout treatment. Patients may require ribociclib dose reduction, interruption, or permanent discontinuation to manage hepatoxicity .
Drug-induced rhabdomyolysis
www.charlydmiller.comDrug-induced rhabdomyolysis Teresa J. Coco and Ann E. Klasner Purpose of review Drug-induced rhabdomyolysis is a common syndrome that is complex and potentially life threatening. This article reviews the pathophysiology, clinical presentations, and common compounds that cause drug-induced rhabdomyolysis. Recent findings
Trastuzumab emtansine – Kadcyla®
www.swagcanceralliance.nhs.ukDrug Induced Liver Injury (DILI) Serum transaminases > 3 x ULN and concomitant total bilirubin > 2× ULN Permanently discontinue Kadcyla in the absence of another likely cause for the elevation of liver enzymes and bilirubin, e.g. liver metastasis or concomitant medication