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Search results with tag "Phase i clinical trial design"
Phase I Clinical Trial Design - National Institutes of Health
brb.nci.nih.govLawrence V Rubinstein, PhD* Richard M Simon, DSc* Biometric Research Branch, National Cancer Institute ... in the beagle dog 23. The use of a second species has been shown to be necessary, ... according to the current state of the model, and that the model be immediately “updated” (that the “posterior” distribution of the free parameter ...
Phase I Clinical Trial Design
linus.nci.nih.govThe statistical operating characteristics of this approach are as follows (Table 2). If at least 2 of 3 patients treated at a particular dose show DLT, we can conclude with 90% confidence that the true probability of DLT at that dose is greater than 20%. (In other words, as we see in Table 2, unless the true probability of DLT at that dose is at