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Search results with tag "Steam in place"
Lyophilization of Complex Drug Products: Formulation ...
lubrizolcdmo.comequipped with clean-in-place (CIP) and steam-in-place (SIP) capabilities for ease of cleaning and sterilization. The Lyophilization Process The main principle behind lyophilization is sublimation, a phase transition (Figure 2) wherein a solvent (almost always water) goes directly from solid to gas without becoming a liquid.
STEAM IN PLACE (SIP)
1v9k2r1cfumt46z0gjpvziz1-wpengine.netdna-ssl.comSIP (Sterilize, or Steam In Place) is a timed sterilization of the upstream and downstream biopharmaceutical production train using clean steam. It is part of a 5 step sanitization routine that occurs after every production batch, and follows the inal rinse after CIP (Clean In Place). SIP ensures that every square inch of the production train that