Search results with tag "Ii clinical trial design and dose finding"

PHASE I/II CLINICAL TRIAL DESIGN AND DOSE FINDING …

Where is the target probability of toxicity 6 DOSE-FINDING IN ONCOLOGY TRADITIONAL 3+3 DESIGN The most widely used design in oncology Subjects are assigned in groups of 3 If only 3 subjects on the current dose, then • no toxicity -> 3 on next higher dose • one toxicity -> add 3 on the same dose • two or more toxicity -> MTD is exceeded

  Design, Clinical, Findings, Dose, Trail, Targets, Ii clinical trial design and dose finding