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embargoed.www.thelancet.comJan 12, 2022 · Prostate cancer Prostate-specific antigen Diagnosis Liquid biopsy 1. Introduction Prostate-specific antigen (PSA) is the most valuable tumor marker for prostate cancer (PCa) diagnosis and prognosis. PSA testing plays a vital role in the early diagnosis of PCa and can reduce prostate can-cer-specific mortality according to European Randomized ...