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Mixed Model Repeated Measures (MMRM)

Mixed Model Repeated Measures (MMRM)

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SSE for the repeated measures ANOVA is 6.833+5.333=12.167 based on 6+6=12 degrees of freedom. Similarly, the SS(Patient) can added to obtain the SS(Patient(Vaccine)) for the repeated measures ANOVA, 11.667+13.667=25.333 with 3+3=6 degrees of freedom. Notice that the sums of squares for the time effect (SS(Visit)) are not additive. Solution

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