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Mechanism of Action - Food and Drug Administration
www.accessdata.fda.govNDA 21-748/S-002 Page 5 There was a rank-order correlation of metformin AUC and Cmax with degree of renal failure. Since metformin can accumulate to toxic levels in patients with renal impairment, administration of
Amaryl® M S.R. (Glimepiride & Metformin HCI) - …
pk.sanofi-aventis.comtherefore be considered. The highest recommended dose per day should be 8 mg of glimepiride and 2000 mg Of metformin. Daily doses Of glimepiride Of more than 6 mg are more effective only