2015年欧州多発性硬化症会議のホッ トな話題からの視点

1 2015 Biogen 2 2015 2015 ACCME Medscape, LLC ACCME 12 Medscape CME James D.

2 Bowen, MD D Acorda Therapeutics; Alexion Pharmaceuticals, Inc.; Avanir Pharmaceuticals; Biogen; EMD Serono, Inc.; Genentech, Inc.; Genzyme Corporation; GlaxoSmithKline; Novartis Pharmaceuticals Corporation; Pfizer Inc; Teva Neuroscience, Inc. Amgen Inc. D FDA D FDA Stephen Krieger, MD Acorda Therapeutics; Bayer HealthCare Pharmaceuticals; Biogen; EMD Serono, Inc.

3 ; Genentech, Inc.; Genzyme Corporation; Questcor Pharmaceuticals, Inc.; Teva Neuroscience, Inc. Mathias Buttmann, MD Teva Neuroscience, Inc. EMD Serono, Inc.; Novartis Pharmaceuticals Biogen Bayer HealthCare Pharmaceuticals; Genzyme Corporation Patricia K. Coyle, MD K AbbVie Inc.; Accordant; Acorda Therapeutics; Bayer HealthCare Pharmaceuticals; Biogen; Genentech, Inc.; Roche; Genzyme Corporation; Sanofi; Mylan Laboratories, Inc.; Novartis Pharmaceuticals Corporation; EMD Serono, Inc.; Teva Neuroscience, Inc.

4 Actelion Pharmaceuticals, Ltd.; Novartis Pharmaceuticals Corporation; Opexa Therapeutics, Giovannoni, MBBCh, PhD : Canbex Therapeutics; GW Pharmaceuticals; EMD Serono, Inc.; Novartis Pharmaceuticals Corporation; Genzyme Corporation; Sanofi; FivePrime Therapeutics; Ironwood Pharmaceuticals, Inc.; Synthon BV; Vertex Pharmaceuticals Incorporated AbbVie Inc.; Biogen; Novartis Pharmaceuticals Corporation; Teva Neuroscience, Inc.; Roche scar Fernandez, PhD Actelion Pharmaceuticals Ltd; Allergan, Inc.; Almirall Prodesfarma, S. A.; Bayer HealthCare Pharmaceuticals; Biogen; EMD Serono, Inc.; Genzyme Corporation; Roche; Teva Neuroscience, Inc.

5 Actelion Pharmaceuticals Ltd; Allergan, Inc.; Almirall Prodesfarma, S. A.; Bayer HealthCare Pharmaceuticals; Biogen; EMD Serono, Inc.; Genzyme Corporation; Roche; Teva Neuroscience, Inc. Actelion Pharmaceuticals Ltd; Allergan, Inc.; Almirall Prodesfarma, S. A.; Bayer HealthCare Pharmaceuticals; Biogen; EMD Serono, Inc.; Genzyme Corporation; Roche; Teva Neuroscience, 2015 Claire S. Riley, MD S Biogen; Novartis Pharmaceuticals Corporation; Teva Neuroscience, Inc. BiogenSD Gena Dolson, MS Medscape Ronald K. Miller, PhD Medscape K Robert Morris, PharmD Medscape CME 2015 10 7 10 31 ECTRIMS MS MS MS MS MS [1] MS 2 MS 3 [1]

6 MS ECTRIMS 2015 MS [2] MS MS MS MS 2 3 [3] [3] MS [2] T2 FLAIR Gd MRI MS MS OCT MRI MS EDSS MSFC MS MS MS International Progressive MS Alliance [2] MS MS [4]MS MS MS D D [5] [5] MS MS Th17 MS [5] MS MS MS 3500 4400 MS 6 [6]

7 6 2015 MS D EBNA1 20 20 MS MS HLA-DRB1*15 HLA-A*02 13 [6] D [6] MS Bj rnevik Nurses Health Study 1984 2004 81,757 Nurses Health Study II 1991 2009 95,452 MS 479 [7] MS 1 5 MS 1 5 [7] MS [7] MS MS [8] MS MS MS T 25 30 [9] MS [10]

8 MRI MRI MS MS T2 FLAIR MRI T1 T1 MRI DTI DTI MT MRI MT MRI fMRI MS 76 Preziosa MRI 5 T2 DTI [11] DTI [11] fMRI MS [12] fMRI [12] fMRI [12]

9 11C-PBR28 PET Herranz 17 MS 11C-PBR28 PET MRI [13] PET MRI MS [13] 11C-PBR28 PET MS T2 MS MRI Uher "clinically isolated syndrome CIS " 6 12 T1 6 [14] CIS Tintor 2 MRI T2 1 1 [15] NEDA NEDA 3 MRI NEDA 4 NEDA 3 Kappos 1 NEDA 6 [16] NEDA NEDA 3 NEDA 4 NEDA 3 NEDA 4 1 6 NEDA 3 3 MRI 4 NEDA 4 [16] 8 2015 CSF NfL Arrambide CIS 1 5 MS NfL MS ng/L ng/L [17] NfL MRI [17]

10 NfL NfL CIS MS 2 MS NfL [18] CSF 14-3-3 CSF 14-3-3 CIS MS [18] 3 1 Th2 CIS MS CIS MS EDSS 3 EDSS 6 [18]MS DMT MS DMT MS DMT Kister DMT MSBase [19] 5 DMT 140 DMT 140 4 DMT [19] 2 DMT PML PML PML JC PML JC Schwab L- CD62L PML [20]L- 2000 L- CD4 PML 5