平成 23 年度報告 毒物劇物指定のための有害性情報 …

1 23 CAS No. 137-26-8 24 3 1 LD50/LC50 >1000 mg/kg GHS 4 5 2000 mg/kg GHS 5 mg/L/4H GHS 4 GHS 1 EU CLP 1. LD50 LC50 2. CAS No. LD50/LC50 30 Chemical Database (CD) MSDS [ ] International Chemical Safety Cards (ICSC) IPCS , [ 2 ] Fire Protection Guide to Hazardous Materials (NFPA, 13th ed.)

2 , 2002) NFPA CRC Handbook of Chemistry and Physics (CRC, 85th, 2004) CRC Merck Index (Merck, 14th ed., 2006) Merck and Company, Inc. ChemID US NLM TOXNET 1 [ ] GESTIS IFA [ ] Registry of Toxic Effects of Chemical Substances (RTECS) US NIOSH ( ) MDL Information Systems, Inc. [ , Inc ] Hazardous Substance Data Bank (HSDB) NLM TOXNET [ ] , Inc [RightAnswer ] International Uniform Chemical Information Database (IUCLID) ECB [ ] IUCLID Chemical Data Sheets Information System Patty s Toxicology (Patty, 5th edition, 2001) Wiley-Interscience JECDB OECD GLP [ ] SAX s Dangerous Properties of Industrial Materials (SAX, 11th edition, 2004) Wiley-Interscience Environmental Health Criteria (EHC) IPCS 3[ ] Concise International Chemical Assessment Documents (CICAD) IPCS EHC [ ] EU Risk Assessment Report (EURAR) EU [ ] Screening Information Data Set (SIDS) OECD [ ] ATSDR Toxicological Profile (ATSDR)

3 US ATSDR [ ] ACGIH Documentation of the threshold limit values for chemical substances (ACGIH , 7th edition, 2001) ACGIH MAK Collection for Occupational Health and Safety (MAK) DFG [ ] TOXLINE US NLM [ ] PubMed US NLM [ ] Google Scholar (Google-S) Google [ ] Google Google [ ] ESIS (European chemical Substances Information System) ECB EU CLP[ ] [ ] Recommendation on the Transport of Dangerous Goods, Model Regulations (TDG 16th ed., 2009; 17th ed., 2011) [ ] [ ] 3. 4 SIDS EHC ACGIH MAK WHO IARC HCN EPA HPV EPA RED SDS CD ( 1) ATSDR ICSC ( 2) CICAD NFPA EURAR CRC ( 3) SIDS ( 11) Merck ( 4) EHC ( 12) ChemID ( 5) ACGIH ( 13) GESTIS ( 6) MAK ( 14) RTECS ( 7) IARC ( 15) HSDB ( 8) HCN ( 16) IUCLID ( 9) JECDB SAX ( 10) EPA HPV ( 17) Patty EPA RED ( 18) SDS ( 19) TDG ( 20) ESIS ( 21) 2-8, 11, 13, 15 Thiuram, Thiram, Tetramethylthiuram disulfide, Bis (dimethylthiocarbamoyl) disulfide CAS 137-26-8 RTECS JO1400000 UN TDG 3077 ICSC 0757 EC (Annex I Index)

4 205-286-2 (006-005-00-4) C6H12N2S4 / (CH3)2N-CS-S-S-CS-N(CH3)2 1 g/cm3 (20 C) 129 C ( kPa) 156 C 89 C ( ) 10-5 mmHg (= Pa) (25 C) 1 18 mg/L / (Log P) 1 mL/m3 (1 ppm) = mg/m3 ( g/L) [1 25 C] 1 5-19 ChemID 5 GESTIS 6 RTECS 7 HSDB 8 IUCLID 9 SAX 10 SIDS 11 EHC 12 ACGIH 13 MAK 14 IARC 15 HCN 16 EPA HPV 17 EPA RED 18 SDS 19 ChemID 5 6 LD50 (LC50) 560 mg/kg 1 1250 mg/kg 2 LDLo 5 g/kg (LD50: >5000 mg/kg) 3 LDLo 1 g/kg (LD50: >1000 mg/kg) 4 500 mg/m3/4H (= 51 ppm/4H)* 5 *: Pa 25 C 106 x kPa /101 kPa = ppm 51 ppm g/L GESTIS 6 LD50 (LC50) 560 mg/kg 1 400 4000 mg/kg 6 / >1000 or >2000 mg/kg 6 mg/L/4H 5 >102 mg/m3/4H 6 300 1000 mg/m3/4H 6 >6225 mg/m3/4H 7 RTECS 7 LD50 (LC50)

5 560 mg/kg 1, 8 1800 mg/kg 8 1250 mg/kg 2 1350 mg/kg 8 4420 mg/m3/4H 8 500 mg/m3/4H 8 HSDB 8 LD50 (LC50) 560 mg/kg 9 1350 mg/kg 10 >2000 mg/kg 11 7 500 mg/m3/4H 9 IUCLID 9 LD50 (LC50) 1800 mg/kg # 12 560 mg/kg 1 2600 mg/kg # 12 1080 mg/kg # 13 1112 mg/kg ( ), 1278 mg/kg ( ) 14 1350 mg/kg 15 >5000 mg/kg 14,16 >2000 mg/kg #a 12 2000 mg/kg # 17 >7940 mg/kg # 13 mg/L/4H # 18 mg/L/4H 5 > mg/L/4H #b 12 > mg/L/4H 19 > mg/L/4H c 14 # : GLP a : b : ( mg/L) ( mg/L) c : SAX 10 LD50 (LC50) 560 mg/kg 1 1350 mg/kg 15 LDLo 1g/kg (LD50.)

6 >1000 mg/kg) 4 500 mg/m3/4H 5 SIDS 11 LD50 (LC50) 4000 mg/kg 1900 mg/kg 20 4000 mg/kg 3800 mg/kg 20 8 * mg/L/4H *: EHC 12 LD50 (LC50) 865 1300 mg/kg 21 780 865 mg/kg 22 1500 2000 mg/kg 22 >2000 mg/kg 23 ACGIH 13 LD50 (LC50) 620 4000 mg/kg 20,24,25 2300 4000 mg/kg 20,26 >2000 mg/kg 24 300 1000 mg/m3/4H 27 MAK 14 LD50 (LC50) 400 4000 mg/kg 20,24,25 1500 4000 mg/kg 20,26 >2000 mg/kg a 24 >2000 mg/kg 12 3500 11500 mg/m3/4H 18 a: 2000 mg/kg 1 IARC 15 LD50 (LC50) 865 mg/kg 25 375 1000 mg/kg 23 1400 5400 mg/kg 20 2300 mg/kg 28 1400 5400 mg/kg 26 9 3300 4500 mg/kg 20 >2000 mg/kg 23 HCN 16 LD50 (LC50) 865 mg/kg 25 640 mg/kg, 620 mg/kg 24 4000 mg/kg, 1900 mg/kg 20 2300 mg/kg 26 4000 mg/kg, 3800 mg/kg 20 >2000 mg/kg 24 300 1000 mg/m3/4H 27 >100 mg/m3/4H 29 EPA HPV 17 LD50 (LC50) 1080 mg/kg a >7940 mg/kg b 2000 mg/kg c mg/m3/4H > mg/L/4H d a: 1 5 631, 794, 1000, 1260 mg/kg 10 b: 1 2 40% 5010 7940 mg/kg 24 c: 2000 mg/kg d.

7 EPA RED 18 LD50 (LC50) 1800 mg/kg >2000 mg/kg > mg/L(/4H) SDS 19 10 40 60 LD50 (LC50) 2018 mg/kg 2089 mg/kg 16* >5000 mg/kg 16* mg/L/4H, mg/L/4H 16* *: SDS SDS GHS 5 4 PubMed [CAS No. 137-26-8 & Acute toxicity] PubMed 7, 10, 12-15, 18 RTECS 7 8 100 mg 24 30 100 mg 8 HSDB 8 31 IUCLID 9 24 32 GLP 13 15 GLP 22 100 mg 24 30 GLP 13 ACGIH 13 1133 HCN 16 34 EPA HPV 17 4 24 SDS 19 GLP 72 16* GLP 100 mg 1 2 16* SDS GHS GHS 2B *.

8 SDS PubMed [CAS No. 137-26-8 & irritation] PubMed 20, 21 20 3077(Environmentally hazardous substance, solid, ), Class ( ), Packing group III ( III) EU CLP/GHS 21 Xn: R20/22-48/22 (Harmful by inhalation and if swallowed= GHS Acute Tox Cat. 4, Harmful: danger of serious damage to health by prolonged exposure if swallowed= GHS STOT RE2), Xi; R36/38 (Irritating to eyes and skin = GHS Eye Irrit Cat. 2, GHS Skin Irrit Cat. 2) , R43 (May cause sensitisation by skin contact = Skin Sens. Cat. 1) , N;R50-53 (Very toxic to aquatic organism, may cause long-term adverse effects in the aquatic environment = Aquatic Acute , Aquatic Chronic cat. 1) 124. P-450 3 19 TCA SH 5.

9 (a) LD50 50 mg/kg LD50 50 mg/kg 300 mg/kg (b) LD50 200 mg/kg LD50 200 mg/kg 1,000 mg/kg (C) ( ) LC50 500 ppm (4hr) LC50 500 ppm (4hr) 2,500 ppm( 4hr) ( ) LC50 mg/L (4hr) LC50 mg/L (4hr) 10 mg/L (4hr) ( ) LC50 mg/L (4hr) LC50 mg/L (4hr) mg/L (4hr) 13 4 3 1 Draize 1 21 3 2 24 48 72 3 GHS 1 5 GHS 1 2/3 GHS 1 1 2 3 1 2A 2B 21 7 LD50 1000 mg/kg 14 LD50 (LC50) ( ) 560 mg/kg ChemID(5), GESTIS(6)

10 , RTECS(7), HSDB(8), IUCLID(9), SAX(10) 1,8,9 640 mg/kg 620 mg/kg HCN(16) 24 865 mg/kg IARC(15), HCN(16) 25 * 1080 mg/kg IUCLID(9), EPA HPV(17) 13 1112 mg/kg ( ) 1278 mg/kg ( ) IUCLID(9) 14 * 1800 mg/kg RTECS(7), IUCLID(9), EPA RED(18) 8,12 ** 2018 mg/kg 2089 mg/kg SDS(19) 16 * 2600 mg/kg IUCLID(9) 12 4000 mg/kg 1900 mg/kg SIDS(11), HCN(16) 20 ** LDLo: 5 g/kg (LD50: >5000 mg/kg) ChemID(5), IUCLID(9), SDS(19) 3,14, 16 * >2000 mg/kg HSDB(8), IUCLID(9), EHC(12), ACGIH(13), MAK(14), IARC(15), HCN(16), EPA RED(18) 11,12,23,24 * 2000 mg/kg IUCLID(9), MAK(14), EPA HPV(17) 12,17 > mg/L/4H GESTIS(6), IUCLID(9), HCN(16), EPA HPV(17), EPA RED(18) 6,12 mg/L/4H