平成 25 年度報告 毒物劇物指定のための有害性情報 …

1 25 N-(2- )1,2- CAS No. 111-40-0 26 3 N-(2 - )-1,2- DETA LD50/LC50 1080 mg/kg GHS 4 1090 mg/kg GHS 4 > mg/L/4H GHS 4 GHS DETA GHS 1 DETA EU GHS 1. DETA LD50 LC50 2. CAS No. LD50/LC50 30 International Chemical Safety Cards (ICSC) IPCS , [ ] Fire Protection Guide to Hazardous Materials (NFPA, 13th ed.)

2 , 2002; 14th ed, 1 2010) NFPA CRC Handbook of Chemistry and Physics (CRC, 94th, 2013) CRC Merck Index (Merck, 14th ed., 2006) Merck and Company, Inc. ChemID US NLM TOXNET 1 [ ] GESTIS IFA [ ] Registry of Toxic Effects of Chemical Substances (RTECS) US NIOSH ( ) MDL Information Systems, Inc. , Inc [ ] Hazardous Substance Data Bank (HSDB) NLM TOXNET [ ] , Inc [ ] International Uniform Chemical Information Database (IUCLID) ECB [ ] Patty s Toxicology (Patty, 5th edition, 2001, 6th edition, 2012) Wiley-Interscience JECDB OECD GLP [ ] SAX s Dangerous Properties of Industrial Materials (SAX, 11th edition, 2004, 12th edition, 2012) Wiley-Interscience Environmental Health Criteria (EHC) IPCS [ ] Concise International Chemical Assessment Documents (CICAD) IPCS EHC 2 [ ] EU Risk Assessment Report (EURAR)

3 EU [ ] Screening Information Data Set (SIDS) OECD [ ] ATSDR Toxicological Profile (ATSDR) US ATSDR [ ] ACGIH Documentation of the threshold limit values for chemical substances (ACGIH , 7th edition, 2010 ) ACGIH MAK Collection for Occupational Health and Safety (MAK) DFG [ ] TOXLINE US NLM [ ] PubMed US NLM [ ] Google Scholar (Google-S) Google [ ] Google Google [ ] Ya h o o Yahoo [ ] Recommendation on the Transport of Dangerous Goods, Model Regulations (TDG 17th ed., 2011; 18th ed., 2013) [ , ] ESIS (European chemical Substances Information System) ECB EU-Annex VI/EU GHS [ ] 3 3.

4 SIDS ICSC ( 1) ATSDR NFPA ( 2) CICAD CRC EURAR Merck ACGIH ( 10) ChemID ( 3) EHC GESTIS ( 4) SIDS ( 11) RTECS ( 5) MAK HSDB ( 6) JECDB IUCLID ( 7) TDG ( 12) SAX ( 8) ESIS ( 13) Patty ( 9) 14 1-8, 10, 14 N-(2 - )-1,2- N-(2 -Aminoethyl)-1,2-ethanediamine, Diethylenetriamine, 3-Azapentane-1,5-diamine, 2,2'-Iminodiethylamine, DETA CAS 111-40-0 RTECS IE1225000 UN TDG 2079 ICSC 0620 EC (Annex VI Index) 203-865-4 (612-058-00-X ) C4H13N3 / NH2CH2CH2 NHCH2CH2NH2 4 1 g/mL (20 C) 207 C ( ) 39 C 97 C( ), 102 C( ) 31 Pa (25 C)[ 37 Pa (20 C)] 1 1000 g/L 25 C / (Log P) 1 mL/m3 (1 ppm) = mg/m3 ( g/L) [1 20 C] 1 mL/m3 (1 ppm) = mg/m3 ( g/L) [1 25 C] 1 3-10 ChemID 3 GESTIS 4 RTECS 5 HSDB 6 IUCLID 7 SAX 8 Patty 9 ACGIH 10 SIDS 11 IUCLID 7 SIDS SIDS ChemID 3 LD50 (LC50) 1080 mg/kg #1 1 1090 mg/kg #2 2 LCLo: 70 mg/m3/4H #3 3 #1.

5 1 Long-Evans 10 819 1430 5 mg/kg #2: 14 950 1240 mg/kg #3 1 5 F344 , , , mg/L 4 3 7 LC50 < mg/L 3 DETA 31 Pa (25 C) 106 x kPa / 101 kPa = ppm (= 1289 mg/m3 = mg/L) mg/L = ppm GESTIS 4 LD50 (LC50) 1080 mg/kg 1 672 mg/kg 4 LCLo: 428 ppm ( mg/L)/4H* IUCLID * 10 9 428 ppm 4 5 IUCLID 7 GESTIS 6 130 ppm/6H/ = 159 ppm/4H = mg/L/4H 5 2 19 19 130 ppm mg/L 2 3 RTECS 5 LD50 (LC50) 1080 mg/kg 1 1090 mg/kg 2 LCLo: 70 mg/m3/4H* 3 *: HSDB 6 LD50 (LC50) 1080 mg/kg 5 2330 mg/kg Patty #1 1090 mg/kg 5 LC0: /8 H* Patty #1 #1: Patty, 1981-1982 *.

6 DETA 31 Pa (25 C) 106 x kPa / 101 kPa = 6 ppm (= 1289 mg/m3 = mg/L) 300 ppm/8H 4 600 ppm/4H IUCLID 7 LD50 (LC50) LC90: mg/L/4H ( = 420 ppm/4H)* 17 *: IUCLID 1 5 14 9/10 SAX 8 LD50 (LC50) 1080 mg/kg 1 1090 mg/kg 2 Patty 9 LD50 (LC50) 1080 mg/kg 1, 18 2330 mg/kg 18 1090 mg/kg 18 LC0: (300 ppm)/8 H = (600 ppm/4H)#1 18 *: 8 ACGIH 10 LD50 (LC50) 1080 mg/kg 2 1090 mg/kg 2 LCLo: >300 ppm/8H* 6 * 7 300 ppm DETA ACGIH DETA T LV-T WA 1 ppm ( mg/m3) SIDS 11 7 LD50 (LC50) 1080 (819-1430) mg/kg 1 1140 mg/kg 7 1539 mg/kg 8 1800 mg/kg 9 1950 mg/kg 11 2330 (2080-2600) mg/kg 2 672 mg/kg 4 1090 (950-1240) mg/kg 2 1040 mg/kg 10 PubMed [CAS No.]

7 111-40-0 & acute toxicity] PubMed 5-10 GESTIS 4 1 2 3 10% DETA 1 50 L 15% 3/4 5% 1 1% RTECS 5 500 mg 11 500 mg 12 DETA 3 mL 2 6 1 3 2 12 HSDB 6 DETA 13 8 5~8 10 14 SAX 8 10 mg 24 2 500 mg 11 500 mg

8 12 mg 2 Patty 9 DETA 16 6 15 5 16 ACGIH 10 DETA Patty 1981 15 100 5 SIDS 11 24 72 1 10 mg 24 2 10 6 5 8 15 5 6 2 3 PubMed [CAS No. 111-40-0 & irritation] PubMed 12, 13 12 2079 (DIETHYLENE TRIAMINE) Class 8 ( ) Packing group ( )II 9 EU GHS 13 Acute Tox.

9 4* (Harmful if swallowed, Harmful if contact with skin; *, mimimum classification), Skin Corr. 1B (Causes severe skin burns and eye damage), Skin Sens. 1 (May cause an allegic skin reaction) 4. DETA 48 40 46 31 43 DETA 4 9 5. (a) LD50 50 mg/kg LD50 50 mg/kg 300 mg/kg (b) LD50 200 mg/kg LD50 200 mg/kg 1,000 mg/kg (C) ( ) LC50 500 ppm (4hr) LC50 500 ppm (4hr) 2,500 ppm( 4hr) ( ) LC50 mg/L (4hr) LC50 mg/L (4hr) 10 mg/L (4hr) ( ) LC50 mg/L (4hr) LC50 mg/L (4hr) mg/L (4hr)

10 10 4 3 1 Draize 1 21 3 2 24 48 72 3 GHS 1 5 GHS 1 2/3 GHS 1 1 2 3 1 2A 2B 21 7 DETA 11 LD50 (LC50) ( ) 1080 mg/kg ChemID(3), GESTIS (4), RTECS(5), HSDB (6), SAX (8), Patty (9), ACGIH (10), SIDS(11) 1, 2 1140 mg/kg SIDS(11) 7 1539 mg/kg SIDS(11) 8 1800 mg/kg SIDS(11) 9 1950 mg/kg SIDS(11) 10 2330 mg/kg SIDS(11) 8 672 mg/kg GESTIS (4), SIDS (11) 4 1040 mg/kg SIDS(11) 10 1090 mg/kg ChemID(3), RTECS(5), HSDB(6), SAX(8),Patty(9), ACGIH(10), SIDS(11) 2, 5, 18 < mg/L/4H (= ppm/4H) ChemID(3), RTECS(5) 3 < 428 ppm/4H (= mg/L/4H) GESTIS(4), IUCLID(7) 17 LC0.