麻酔薬および麻酔関連薬使用ガイドライン 第3版 …

1 Dobutamine hydrochloride 233. adenosine triphosphate disodium 184 nicardipine hydrochloride 235. adrenaline 187 nicorandil 238. atropine sulfate hydrate 190 nitroglycerin 240. amiodarone hydrochloride 194 sodium nitroprusside 243. aminophylline hydrate 196 nifedipine 245. amrinone 198 noradrenaline 247. alprostadil vasopressin 250. alprostadil alfadex 200 hydralazine hydrochloride 252. isoprenaline hydrochloride 203 phenytoin 255. esmolol hydrochloride 206 . etilefrine hydrochloride 208 phenylephrine hydrochloride 257. ephedrine hydrochloride 210 phentolamine mesilate 259. flecainide acetate 261.

2 Olprinone hydrochloride hydrate 212 . procainamide hydrochloride 263. colforsin daropate hydrochloride 215 . digoxin 217 propranolol hydrochloride 265.. disopyramide verapamil hydrochloride 268. disopyramide phosphate 219 milrinone 271. cibenzoline succinate 221 mexiletine hydrochloride 273.. isosorbide dinitrate 223 landiolol hydrochloride 275. diltiazem hydrochloride 226 .. deslanoside 229 magnesium sulfate hydrate 277. dopamine hydrochloride 231.. 1 .. 3 2009 - 2014 3 4 -1 183.. adenosine triphosphate disodium 1 1. 1 ATP . ATP 2. ADP . AMP 3. 1,2 .. P1 . 4. A1, A2A, A2B, A3 . ATP P2 P2X P2Y.

3 5. ATP P1 . 1,2 . 6. 2 7. ATP . P2X . P2Y 8. NO A2 . 3 9. ATP . 10. ATP P2 . 11. ATP . A1 .. 12. 3,4 .. 13. ATP . A1 A3 . 14. 3 . 15. A2 16.. COPD . A2 17. 5 .. 18. 19. ATP . P2X 20. ATP P2Y ATP . 1 21. ATP . A2 22. A1 . ATP 1 . 23. 1 . 24. 3 ATP .. 25. ATP . 26.. 27. 28. 2 29. ATP 30.. 31. 1 PSVT ATP . PSVT 32. 90% . WPW PSVT . 2,4 . 33. ATP . ATP VT . 4 . 34. VT . QRS PSVT VT 4 35. 2 ATP ATP . 36.. 37. 6,7 . NP . ATP . 38. 6,7 .. 39. ATP NP . ATP NP .. 40. NP . 8 .. 8 41.. 42. 43. 3 44. 1 PSVT 1 ATP 10 20 mg . 2 . ATP 45.. 46.. 47. 2 ATP 200 500 g/kg/min 48. 3 2009 3 -2 184.. 7 1. 2. 4 3.

4 ATP . 1 - . 4. 1 - . 5. 6. 1 7. 8. 9.. 10. 11. QT Torsades de pointes 12. 13. 14. 2 15. 16. 17. 18. 19.. 20. 21. COPD 22. 3 ATP .. 23.. 24.. 25. ST-T QT QRS 26.. 27.. 28.. 29. 30. COPD .. 31. 32. / .. 33. ATP . 34. 140 g/kg/min . 35. 120 g/kg/min . 6 1 2 . 36. 2 . 37. 4 38. 5 . 39. 40. 6 41.. ATP . 42. 43.. 44. 45. 5 46. -a -b 47. -c 48. 1 Hayashida M, Fukuda K, Fukunaga A : Clinical application of adenosine and ATP for pain control. J Anesth 2005 ; 19 : 225-235 49.. 50. 2 Faulds D, Chrisp P, Buckley MM : Adenosine. An evaluation of its use in cardiac diagnostic procedures, and in the treatment of paroxysmal supraventricular tachycardia.

5 Drugs 1991 41 : 596-624 51. 3 2009 3 -3 185.. 3 Rongen GA, Floras JS, Lenders JW, et al : Cardiovascular pharmacology of purines. Clin Sci Lond 1997 ; 92 : 13-24 1. 4 Malcolm AD, Garratt CJ, Camm AJ : The therapeutic and diagnostic cardiac electrophysiological uses of adenosine. Cardiovasc 2. Drugs Ther 1993 : 7 ; 139-47 3. 5 Polosa R : Adenosine-receptor subtypes : their relevance to adenosine-mediated responses in asthma and chronic obstructive 4. pulmonary disease. Eur Respir J 2002 ; 20 : 488-96 . 6 Fukunaga AF, Flacke WE, Bloor BC : Hypotensive e ects of adenosine and adenosine triphosphate compared with sodium ni- 5.

6 Troprusside. Anesth Analg 1982 ; 61 : 273-8 6. 7 : ATP 1984 ; 8 : 967-972 -c 7. 8 Kien ND, White DA, Reitan JA, et al : Cardiovascular function during controlled hypotension induced by adenosine triphos- 8. phate or sodium nitroprusside in the anesthetized dog. Anesthesiology 1985 ; 63 : 517-25 . 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 3 2009 3 -4 186.. adrenaline epinephrine .. 1 1 1. 1 2. 2 3. 1 .. 4.. 5.. 6.. 7. 2 .. 8.. 9.. 10. 11.. 12.. 13. 2 . 14. 3 15.

7 16. 17.. - - - 18. 19. 20. 2 21. 1 .. 22. 1 .. 23. 24. 2 2 .. 25. 26. 3 27. 4 1 . 2 .. 28. 2 . 5 .. 29.. 30. 3 . 6 . 31. 32. 4 . 7 .. 33. 34. 5 6 . 8 35. T 36. 37. 3 38. 1 mg/kg 1000 . 2 . 1 mg/mL . 3 20 39. 2 . 2 40. mg 1000 . 1 mg/mL . 15 20 mg 1 . mg/ 41. mL 5 1 4 g/min 42. 43. mg/kg 20 44. 3 1 g/min . 45. 4 2 10 g/min . 2 . 46. 5 2 .. 47. 3 2009 - 2014 3 4 -5 187.. 1 1 mg 1 mL 20 mL 1. 3 5 2 5 10 mL 2. 3. mg/kg . mg/kg mg/kg 4. 3 5 . 5. 6 . 1 mg/mL 20 mg/mL . 4 . 6.. 1000 1 mg/mL 5000 mg/. 7. mL . 8. 7 5 . 6 .. 20 mL mL 20 9. mg/mL 2 3 mL . 10. 11. 4 12. 1 . 13. 14. 7 . 2 . 15.. 16.. 17.

8 18. 19.. 20. 3 21.. 22.. 23. 8 .. 24. 9 .. 25.. 26.. 27.. 28.. 29. 30.. 31.. 32. 4 . 33.. 34. 35. 5 36. 37. T .. 38.. 39. 6 . 40. 7 41. 42. 5 43. -a -b 44. -c 45. 1 Hoffman BB, Lefkowitz RJ : Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists. In Hardman 46. JG, Gilman AG, Limbird LE eds ; Goodman & Gilman s The Pharmacological Basis of Therapeutics. 9th ed. New York, McGrawHill, 1996, pp 204-209 47. 2 American Heart Association. Inc. ACLS AHA 48. 2010 2012, pp S739-S778 49. 3 Niemi G, Breivik H : Epinephrine markedly improves thoracic epidural analgesia produced by a small-dose infusion of ropiva- 50.

9 Caine, fentanyl, and epinephrine after major thoracic or abdominal surgery : a randomized, double-blinded crossover study with and without epinephrine. Anesth Analg 2002 ; 94 : 1598-1605 51. 3 2009 - 2014 3 4 -6 188.. 4 1992 ; 41 : 979-983 1. 5 Takahashi S, Tanaka M, Toyooka H : The e cacy of hemodynamic and T-wave criteria for detecting intravascular injection of 2. epinephrine test dose in propofol-anesthetized adults. Anesth Analg 2002 ; 94 : 717-722 . 3. 6 Minzter BH, Johnson RF, Grimm BJ : The practice of thoracic epidural analgesia:a survey of academic medical centers in the United States.

10 Anesth Analg 2002 ; 95 : 472-475 4. 7 Kulier AH, Tumer LA, Vodacovic S, et al : Multiple agents potentiate 1-adrenoceptor-induced conduction depression in ca- 5. nine cardiac Purkinje fibers. Anesthesiology 2000 ; 92 : 1713-1721 6. 8 Navarro R, Weiskopf RB, Moore MA, et al : Humans anesthetized with sevoflurane or isoflurane have similar arrhythmic re- 7. sponse to epinephrine. Anesthesiology 1994 ; 80 : 545-549 . 9 2 1998 ; 47 : 955- 8. 962 c 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46.