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第7回細胞接着と細胞骨格 - 岡山大学 情報 ...

CAM: Cell-adhesion molecules Cytoskeleton y Actin filament Microfilament Actin filament; Microfilament Microtubule intermediate filament P1 P1 - C C

教科書p142 繊維状分子 基底の繊維や細かいネットワークを形成 哺乳動物の体内で一番多いタンパク質(約3分の1) • フィブロネクチン 分子量約25万のサブユニット2つがジスルフィド結 合した二量体 コラーゲン結合ドメインでコラーゲンに、細胞結合ド

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Transcription of 第7回細胞接着と細胞骨格 - 岡山大学 情報 ...

1 CAM: Cell-adhesion molecules Cytoskeleton y Actin filament Microfilament Actin filament; Microfilament Microtubule intermediate filament P1 P1 - C C P1 P14

2 RGD Arg-Gly-Asp) P14 - CAM P14 CAM) CAM CAM E P14 adherensjunction E adherensjunction E Ca2+ E F

3 P14 - P14 - epithelium epithelium polarity Tight junction JAM (Junctional adhesion molecule JAM (Junctional adhesion molecule JAM Desmosome P14 Gap junction P14 P14))

4 15 Hemidesmosome P14 IV PAF ICAM CAM P14 10 3 P1 3 1 25 2 7 7

5 C N P142IV IV P1 P1 Cytoskeleton y Actin filament Microfilament Actin filament; Microfilament Microtubule intermediate filament ifil ifil nm Actinfilament Microfilament G- G-actin polymerization G Gactin polymerization ATP ADP G Gti G- G-actin ATP G- Mg2+ K+ gNa+ ATP ADP depolymerization G- G-actin plus end minus end plus end minus end

6 - P20 -210 ATP RNA RNA P20 ATP ATP I II P20 Microtubule - -tubulin - -tubulin - GTP - GTP GDP GTP GDP GTP

7 - GTP GTP GTP P2 - ATP P2 P2

8


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