ANNEX II, Last update: 01/12/2021 - European Commission

1 File creation date: 20/11/2018 ANNEX II (CosIng 2), Last update: 24/04/2018 LIST OF SUBSTANCES PROHIBITED IN COSMETIC PRODUCTSR eferencenumberSubstance identificationChemical name / INNCAS NumberEC NumberUpdate Date1N-(5-Chlorobenzoxazol-2-yl)acetamid e35783-57-4-17/10/20102(2-Acetoxyethyl)t rimethylammonium hydroxide (Acetylcholine) and its salts51-84-3200-128-917/10/20103 Deanol aceglumate (INN)3342-61-8222-085-515/10/20104 Spironolactone (INN)52-01-7200-133-615/10/20105[4-(4-Hy droxy-3-iodophenoxy)-3,5-diiodophenyl]ac etic acid (Tiratricol (INN)) and its salts51-24-1200-086-117/10/20106 Methotrexate (INN)59-05-2200-413-815/10/20107 Aminocaproic acid (INN) and its salts60-32-2200-469-317/10/20108 Cinchophen (INN), its salts, derivatives and salts of these derivatives132-60-5 /5949-18-8205-067-1 /227-710-517/10/20109 Thyropropic acid (INN) and its salts51-26-3-17/10/201010 Trichloroacetic acid76-03-9200-927-215/10/201011 Aconitum napellus L.

2 (leaves, roots and galenical preparations)84603-50-9283-252-615/10/20 1012 Aconitine (principal alkaloid of Aconitum napellus L.) and its salts302-27-2206-121-715/10/201013 Adonis vernalis L. and its preparations84649-73-0283-458-615/10/201 014 Epinephrine (INN)51-43-4200-098-715/10/201015 Rauwolfia serpentia L., alkaloids and their salts90106-13-1290-234-117/10/201016 Alkyne alcohols, their esters, ethers and salts--17/10/201017 Isoprenaline (INN)7683-59-2231-687-715/10/201018 Allyl isothiocyanate57-06-7200-309-215/10/2010 19 Alloclamide (INN) and its salts5486-77-1-17/10/201020 Nalorphine (INN), its salts and ethers62-67-9200-546-117/10/201021 Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription andreferred to in Resolution AP (69) 2 of the Council of Europe300-62-9206-096-209/03/2011224,4'- Methylene bis(2-chloroaniline) and its salts.

3 2,2'-Dichloro-4,4'-methylenedianiline and its salts101-14-4202-918-904/10/201622 Aniline, its salts and its halogenated and sulphonated derivatives62-53-3200-539-317/10/201023 Betoxycaine (INN) and its salts3818-62-0-17/10/201024 Zoxazolamine (INN)61-80-3200-519-417/10/201025 Procainamide (INN), its salts and derivatives51-06-9200-078-817/10/201026 Benzidine92-87-5202-199-120/10/201027 Tuaminoheptane (INN), its isomers and salts123-82-0204-655-517/10/2010 Page 1/47 ReferencenumberSubstance identificationChemical name / INNCAS NumberEC NumberUpdate Date28 Octodrine (INN) and its salts543-82-8208-851-117/10/2010292-Amin o-1,2-bis(4-methoxyphenyl)ethanol and its salts530-34-7-17/10/2010301,3-Dimethylpe ntylamine and its salts105-41-9203-296-115/10/2010314-Amin osalicylic acid and its salts65-49-6200-613-515/10/201032 Toluidines, their isomers, salts and halogenated and sulphonated derivatives26915-12-8248-105-217/10/2010 33 Xylidines, their isomers, salts and halogenated and sulphonated derivatives1300-73-8215-091-417/10/20103 4 Imperatorin (9-(3-methylbut-2-enyloxy)furo[3,2-g]chr omen-7-one)482-44-0207-581-115/10/201035 Ammi majus L.

4 And its galenical preparations90320-46-0291-072-417/10/201 0362,3-Dichloro-2-methylbutane507-45-9-1 5/10/201037 Substances with androgenic effect15/10/201038 Anthracene oil120-12-7204-371-117/10/201038 Distillates (coal tar), pitch101316-49-8309-855-704/10/201638 Distillates (coal tar), pitch, heavy oils91995-51-6295-312-904/10/201638 Distillates (coal tar), pitch, pyrene fraction91995-52-7295-313-404/10/201639 Antibiotics17/10/201040 Antimony and its compound7440-36-0231-146-517/10/201041 Apocynum cannabium L. and its preparations84603-51-0283-253-115/10/201 042 Apomorphine ((R)-5,6,6a,7-tetrahydro-6-methyl-4H-dib enzo[de,g]quinoline-10,11-diol)) and its salts58-00-4200-360-017/10/201043 Arsenic acid and its salts7778-44-1-23/11/201643 Arsenic and its compounds7440-38-2231-148-607/01/201144 Atropa belladonna L.

5 And its preparations8007-93-0232-365-915/10/2010 45 Atropine, its salts and derivatives51-55-8200-104-815/10/201046 Barium salts, with the exception of barium sulphide under the conditions laid down in ANNEX III and of barium sulfate, lakes, salts and pigments prepared from thecolouring agents when listed in ANNEX IV17/10/201046 Beryllium compounds with the exception of aluminium beryllium silicates7440-41-7-23/11/201647 Benzene71-43-2200-753-728/10/201047 Distillates (petroleum), C7-9, C8-rich, hydrodesulfurized dearomatized, if it contains > w/w benzene101316-56-7309-862-504/10/201647 Extract residues (coal tar), benzole fraction alk., acid ext., if it contains > w/w benzene101316-63-6309-868-804/10/201647 Extract residues (coal), light oil alk.

6 , acid ext., indene fraction, if it contains > w/w benzene101316-62-5309-867-204/10/201647 Hydrocarbon oils, arom., mixed with polyethylene and polypropylene, pyrolyzed, light oil fraction, if it contains > w/w benzene100801-63-6309-745-904/10/201647 Hydrocarbons, C6-8, hydrogenated sorption-dearomatized, toluene raffination, if it contains > w/w benzene101316-66-9309-870-904/10/201647 Hydrocarbons, C6-rich, hydrotreated light naphtha distillates, solvent-refined, if it contains > w/w benzene101316-67-0309-871-404/10/201647 Naphtha (petroleum), hydrodesulfurized full-range coker, if it contains > w/w benzene101316-76-1309-879-804/10/2016 Page 2/47 ReferencenumberSubstance identificationChemical name / INNCAS NumberEC NumberUpdate Date47 Tar acids, brown-coal, crude, if it contains > w/w benzene101316-86-3309-888-704/10/201648 Benzimidazol-2(3H)-one615-16-7210-412-41 5/10/201049 Benzazepines and benzodiazepines12794-10-4-17/10/2010501- Dimethylaminomethyl-1-methylpropyl benzoate (amylocaine) and its salts644-26-8211-411-115/10/2010512,2,6- Trimethyl-4-piperidyl benzoate (eucaine) and its salts500-34-5-17/10/201052 Isocarboxazid (INN)59-63-2200-438-417/10/201053 Bendroflumethiazide (INN)

7 And its derivatives73-48-3200-800-117/10/201054 Beryllium and its compounds7440-41-7231-150-717/10/201055 Bromine, elemental7726-95-6231-778-115/10/201056 Bretylium tosilate (INN)61-75-6200-516-817/10/201057 Carbromal (INN)77-65-6201-046-617/10/201058 Bromisoval (INN)496-67-3207-825-717/10/201059 Brompheniramine (INN) and its salts86-22-6201-657-817/10/201060 Benzilonium bromide (INN)1050-48-2213-885-517/10/201061 Tetrylammonium bromide (INN)71-91-0200-769-415/10/201062 Brucine357-57-3206-614-715/10/201063 Tetracaine (INN) and its salts94-24-6202-316-617/10/201064 Mofebutazone (INN)2210-63-1218-641-117/10/201065 Tolbutamide (INN)64-77-7200-594-317/10/201066 Carbutamide (INN)339-43-5206-424-417/10/201067 Phenylbutazone (INN)50-33-9200-029-017/10/201068 Cadmium chloride10108-64-2233-296-704/10/201668 Cadmium sulphate10124-36-4233-331-604/10/201669 Cantharides, Cantharis vesicatoria92457-17-5296-298-715/10/2010 70 Cantharidine56-25-7200-263-317/10/201071 Phenprobamate (INN)673-31-4211-606-117/10/201072 Nitroderivatives of carbazole15/10/201073 Carbon disulphide75-15-0200-843-615/10/201074 Catalase9001-05-2232-577-115/10/201075 Cephaeline and its salts483-17-0207-591-615/10/201076 Chenopodium ambrosioides L.

8 (essential oil)8006-99-3-17/10/2010772,2,2-Trichlor oethane-1,1-diol302-17-0206-117-515/10/2 01078 Chlorine7782-50-5231-959-515/10/2010 Page 3/47 ReferencenumberSubstance identificationChemical name / INNCAS NumberEC NumberUpdate Date79 Chlorpropamide (INN)94-20-2202-314-517/10/201080 Diphenoxylate (INN) hydrochloride3810-80-8223-287-615/10/201 0814-Phenylazophenylene-1,3-diamine citrate hydrochloride (Chrysoidine citrate hydrochloride)5909-04-6-17/10/201082 Chlorzoxazone (INN)95-25-0202-403-917/10/2010832-Chlor o-6-methylpyrimidin-4-yldimethylamine (crimidine-ISO)535-89-7208-622-617/10/20 1084 Chlorprothixene (INN) and its salts113-59-7204-032-817/10/201085 Clofenamide (INN)671-95-4211-588-517/10/201086N,N-bi s(2-Chloroethyl)methylamine N-oxide and its salts126-85-2-17/10/201087 Chlormethine (INN) and its salts51-75-2200-120-517/10/201088 Cyclophosphamide (INN) and its salts50-18-0200-015-417/10/201089 Mannomustine (INN) and its salts576-68-1209-404-317/10/201090 Butanilicaine (INN) and its salts3785-21-5-17/10/201091 Chlormezanone (INN)80-77-3201-307-417/10/201092 Triparanol (INN)78-41-1201-115-017/10/2010932-[2-(4 -Chlorophenyl)-2-phenylacetyl]indan 1,3-dione (chlorophacinone - ISO)3691-35-8223-003-015/10/201094 Chlorphenoxamine (INN)77-38-3-17/10/201095 Phenaglycodol (INN)79-93-6201-235-317/10/201096 Chloroethane75-00-3200-830-515/10/201097 Chromium (VI)

9 Compounds, with the exception of barium chromate and of compounds specified elsewhere in this Annex18540-29-9-23/11/201697 Chromium; chromic acid and its salts7440-47-3231-157-517/10/201097 Zinc chromates including zinc potassium chromate7440-47-3231-157-504/10/201698 Claviceps purpurea Tul., its alkaloids and galenical preparations84775-56-4283-885-815/10/201 099 Conium maculatum L. (fruit, powder, galenical preparations)85116-75-2285-527-615/10/20 10100 Glycyclamide (INN)664-95-9211-557-617/10/2010101 Cobalt benzenesulphonate23384-69-2-17/10/201010 2 Colchicine, its salts and derivatives64-86-8200-598-529/10/2010103 Colchicoside and its derivatives477-29-2207-513-015/10/201010 4 Colchicum autumnale L. and its galenical preparations84696-03-7283-623-215/10/201 0105 Convallatoxin508-75-8208-086-315/10/2010 106 Anamirta cocculus L.

10 (fruit)15/10/2010107 Croton tiglium L. (oil)8001-28-3-17/10/20101081-Butyl-3-(N -crotonoylsulphanilyl)urea52964-42-8-17/ 10/2010109 Curare and curarine8063-06-7 /232-511-1 /15/10/2010 Page 4/47 ReferencenumberSubstance identificationChemical name / INNCAS NumberEC NumberUpdate Date22260-42-0244-880-6110 Synthetic curarizants15/10/2010111 Hydrogen cyanide and its salts74-90-8200-821-615/10/2010112 Feclemine (INN); 2-(alpha-Cyclohexylbenzyl)-N,N,N',N'-tet raethyl-1,3-propanediamine3590-16-7-17/1 0/2010113 Cyclomenol (INN) and its salts5591-47-9227-002-617/10/2010114 Sodium hexacyclonate (INN)7009-49-615/10/2010115 Hexapropymate (INN)358-52-1206-618-915/10/2010116 Dextropropoxyphene (INN)469-62-5207-420-515/10/2010117O,O'- Diacetyl-N-allyl-N-normorphine.