BD Gentest™ 薬物動態研究用製品 希望小売価格一 …

1 1)45211727,000 27,000 45211617,000 17,000 4521157,000 7,000 45215627,000 27,000 45216126,000 26,000 45216529,000 29,000 45217226,000 26,000 45218326,000 26,000 45296117,000 17,000 4528617,000 7,000 45221035,000 35,000 45213828,000 28,000 45214138,000 38,000 45214238,000 38,000 45214338,000 38,000 45214438,000 38,000 45213238,000 38,000 45213338,000 38,000 45213438,000 38,000 45213538,000 38,000 45213638,000 38,000 45213738,000 38,000 4528016,900 30,000 4528186,900 20,000 4528356,900 12,000 4528426,900 12,000 4528646,900 18,000 4528956,900 12,000 45270110,000 10,000 45270210,000 14,000 4522209,000 14,000 45279110,000 10,000 45279210,000 24,000 4525018,300 8,300 4525028,300 12,000 4525917,400 7,400 4525815.

2 300 10,000 4525117,000 10,000 4525217,800 14,000 4525227,800 30,000 4525937,800 60,000 4525947,800 60,000 45231111,000 30,000 45231311,000 30,000 4522018,600 12,000 45260113,000 13,000 45260213,000 18,000 45269312,000 12,000 45237114,000 14,000 45232215,000 24,000 45232114,000 14,000 (CD-1 ) (Gottingen, ) ( , ) S9 (Yucatan, ) (Cinclair, ) (Dunkin-Hartley, ) (New Zealand White, ) ( , ) ( , ) (Fischer 344, ) (Fischer 344, ) S9 (Fischer 344, ) S9 (Dunkin-Hartley, ) (SD, ) S9 (SD, ) (Wister Han, ) (Fischer 344, ) (CD-1, ) S9 (CD-1, ) S9 (SD, ) (SD, ) (HG95) CYP3A5(*3*3) Wild Type (HH31) (HH18) (HH35) P450 CYP2D6 CYP2C9 CYP2C19 Allelic Variants and Wild TypesBD 150 BD 150 S9BD 150 (CD-1, ) (B6C3F1, ) CYP2C8(*3*3) UGT1A1(*28*28) UGT1A1(*1*28) UGT1A1(*1*1) Wild Type CYP3A5(*1*1) CYP3A5(*1*3) (HG42) (HG64) High/Low P450 Panel S9 50 20 CMV 3) 2)BD Gentest 23 2 1 1 1) 3)

3 2)BD Gentest 23 2 1 45241325,000 25,000 45241125,000 34,000 45249417,000 17,000 45249217,000 28,000 45242425,000 60,000 45234075,000 75,000 45234175,000 75,000 45431076,000 120,000 45470128,000 48,000 45470328,000 48,000 45483030,000 48,000 45450023,500 23,500 45460017,000 17,000 45446015,000 15,000 mL 8,300 8,300 mL 24,000 24,000 mL 10,000 10,000 mL 28,000 28,000 45511120,000 20,000 45510320,000 20,000 45510420,000 20,000 45511016,000 16,000 45511216,000 16,000 45511819,000 19,000 45510916,000 16,000 45511924,000 24,000 45511724,000 24,000 45510620,000 20,000 mL 23,000 23,000 mL 69,000 69.

4 000 45510818,500 18,500 mL 11,000 11,000 mL 28,000 28,000 45629913,000 68,000 45624425,000 22,000 45621136,000 32,000 45620333,000 30,000 45622036,000 32,000 45620452,000 46,000 45625442,000 38,000 45621036,000 32,000 45625564,000 56,000 45621248,000 44,000 45625233,000 30,000 45621848,000 44,000 45625833,000 30,000 45620952,000 46,000 45624253,000 46,000 45622252,000 46,000 45621933,000 30,000 45625948,000 44,000 45621733,000 30,000 45620633,000 30,000 CYP3A4 + ( ) P450 + b5 CYP2E1 + + b5 CYP2C18 + CYP2C19 + CYP2C19 + + b5 CYP2D6*1 (Val374) + CYP2C9*1 (Arg144) + CYP2C9*1 (Arg144) + + b5 CYP2C9*2 (Cys144) + CYP2C9*3 (Leu359) + + b5 CYP2B6 + CYP2B6 + + b5 CYP2C8 + CYP2C8 + + b5 CYP2E1 + CYP1B1 + CYP2A6 + CYP2A6 + + b5Sf9 CYP1A1 + CYP1A2 + Epoxide HydrolaseBD Supersomes CYP CYP2A6 + CYP1A1 + CYP1A2 ( ) ( ) ( ) ( , ) 10^6 (CD-1, ) 2 10^6 (SD, ) 5 10^6 (SD, ) 5 10^6 ( ) ( ) S9 ( ) S9 ( ) CYP2C19 CYP2D6*1 (Val374) + CYP2B6 CYP2C8 + CYP2C9*1 (Arg144)

5 + CYP2C9*2 (Cys144) + 2 1) 3) 2)BD Gentest 23 2 1 45626439,000 34,000 45620736,000 32,000 45620233,000 30,000 45623552,000 46,000 45625628,000 26,000 45623764,000 56,000 45622136,000 32,000 45627237,000 32,000 45627337,000 32,000 45627437,000 32,000 45627539,000 34,000 45626034,000 30,000 45607836,000 36,000 45651422,000 22,000 45651137,000 32,000 45650337,000 32,000 45651937,000 24,000 45650537,000 37,000 45651037,000 32,000 45653637,000 32,000 45653137,000 32,000 45653237,000 37,000 45653337,000 37,000 45651737,000 32,000 45651337,000 32,000 45652137,000 32,000 45650137,000 32,000 45650237,000 32,000 45662137,000 32,000 45661237,000 32,000 45624425,000 22,000 45624136,000 32,000 45623366,000 58,000 45624537,000 32,000 45619913,000 30,000 45628139.

6 000 34,000 45628239,000 34,000 45628013,000 13,000 45628339,000 34,000 45628439,000 34,000 45640010,000 10,000 45641129,000 26,000 45641329,000 26,000 45641429,000 26,000 45641629,000 26,000 45640739,000 34,000 45641836,000 32,000 45641929,000 26,000 45641035,000 32,000 45642439,000 34,000 45642732,000 28,000 45643534,000 30,000 45643739,000 34,000 UGT2B15 UGT2B17 UGT1A9 UGT1A10 UGT2B4 UGT2B7 UGT1A4 UGT1A6 UGT1A7 UGT1A8 Monoamine Oxidase B (MAO-B)UGT UGT1A1 UGT1A3 NAT1 NAT2 Monoamine Oxidase (MAO) Monoamine Oxidase A (MAO-A) FMO3BD Supersomes P450 FMO5 CYP2C21 + + b5 CYP3A12 + + b5 P450 + b5 FMO1 CYP2D2 + CYP2E1 + + b5 CYP3A1 + + b5 CYP3A2 + + b5 CYP19 (Aromatase) + CYP2B1 + + b5 CYP2C6 + + b5 CYP2C11 + + b5 BD Supersomes / CYP CYP4F2 + + b5 CYP4F3A + + b5 CYP4F3B + + b5 CYP4F12 + + b5 CYP3A5 + CYP3A5 + + b5 CYP3A7 + + b5 CYP4A11 + CYP2J2 + + b5 CYP3A4 + CYP3A4 + + b5 NADPH-P450 CYP1A1 + CYP1A2 + CYP2A1 + + b5 CYP2A2 + + b5 CYP2C12 + + b5 CYP2C13 + + b5 CYP2D1 + 3 1) 3)

7 2)BD Gentest 23 2 1 45122033,000 30,000 45120012,000 12,000 45130030,000 30,000 45132015,000 12,000 4512019,000 9,000 4512029,000 9,000 459500177,000 120,000 459420177,000 120,000 459220177,000 120,000 459320177,000 120,000 459300177,000 120,000 459400177,000 120,000 459200177,000 120,000 459620177,000 120,000 459100177,000 120,000 459110177,000 120,000 459120177,000 120,000 459520177,000 120,000 45320014,000 14,000 45327038,000 30,000 45325738,000 30,000 45345638,000 30,000 45333238,000 30,000 45333338,000 30,000 45322838,000 30,000 45325138,000 30,000 45323238,000 30,000 45325038,000 30,000 45345738,000 30,000 45344038,000 30,000 45343438,000 30,000 45334038,000 30,000 45333438,000 30,000 45322938,000 30,000 45323138.

8 000 30,000 45323038,000 30,000 45350064,000 64,000 45327178,000 78,000 45350278,000 78,000 45345578,000 78,000 45345078,000 78,000 45352078,000 78,000 45325278,000 78,000 45334578,000 78,000 45350178,000 78,000 45351078,000 78,000 45352378,000 78,000 455631140,000 140,000 455661140,000 140,000 455663140,000 140,000 455621140,000 140,000 455622140,000 140,000 455627140,000 140,000 OATP8*1 NTCP OAT1 OAT3 OATP1 Mrp2 MRP1 PGP OATP2 SLC Bsep Mrp1 Bcrp Mdr1a MRP1 MRP2 MRP3 PGP PGP ABC BSEP Mdr1b MRP2 Mrp2 MRP3 PGP(MDR1) Bcrp Bcrp BCRP (Arg482)

9 ABC Mdr1a Mdr1b Mrp1 Bcrp UGT Reaction Mix - Solution AUGT Reaction Mix - Solution B pH HTS CYP2E1/MFC pH HTS CYP1A2/CECP450 HTS CYP2A6/CoumarinP450 HTS CYP2B6/EFCBD Supersomes P450 HTS NADPH Regenerating System Solution ANADPH Regenerating System Solution BP450 HTS CYP2C8/DBFP450 HTS CYP2C9/MFCP450 HTS CYP2C19/CECP450 HTS CYP2D6/AMMCP450 HTS CYP3A4/BFCP450 HTS CYP3A4/BQ BCRP (Arg482) BCRP (Thr482) ABC ABC P450 HTS CYP3A4/DBFP450 HTS CYP19/MFC 4 1) 3) 2)BD Gentest 23 2 1 455628140,000 140,000 455611140,000 140,000 455651140,000 140,000 455652140,000 140,000 455671140,000 140,000 455672140,000 140,000 455641140,000 140,000 455644140,000 140,000 455690140,000 140,000 455683140,000 140,000 455601123,000 123,000 45560340,000 40,000 458312111,000 80,000 45832684,000 80,000 45832885,000 80,000 45831967,000 80,000 45836684,000 80,000 45832184,000 80,000 45833484,000 80,000 45810683,000 80,000 45821183,000 80,000 45822687,000 80,000 45821987,000 80,000 45820983,000 80,000 458234107,000 80,000 45823583,000 80,000 458243111,000 111,000 458245111,000 111,000 45824683,000 80,000 45825484,000 80,000 458511111,000 80,000 45841095,000 80,000 45841199.

10 000 80,000 45841699,000 80,000 45842799,000 80,000 45170112,000 7,000 4517005 mg 81,000 30,000 45170525 mg 193,000 90,000 45101426,000 18,000 45101520,000 9,000 4517705 mg 13,000 10,000 45177525 mg 37,000 30,000 4517305 mg 61,000 20,000 45173525 mg 193,000 60,000 4517205 mg 61,000 20,000 45172525 mg 193,000 60,000 45176115,000 80,000 45173112,000 10,000 45172112,000 7,000 4517605 mg 54,000 20,000 45176525 mg 174,000 60,000 4517405 mg 18,000 10,000 45174525 mg 61,000 30,000 45104134,000 28,000 4517505 mg 61,000 30,000 45175525 mg 193,000 90,000 WB-FMO3 FMO3 WB-FMO5 FMO5 3-O-MethylfluoresceinDibenzylfluorescein (DBF)7-Benzyloxy-4-(trifluoromethyl)coua mrin (BFC)7-Benzyloxyquinoline (7-BQ)7-Methoxy-4-(aminomethyl)-coumarin (MAMC)7-Methoxy-4-(trifluoromethyl)couma rin (MFC)7-hydroxy-4-(aminomethyl)-coumarin (HAMC)7-Hydroxy-4-(trifluoromethyl)couma rin (HFC)Cholyl-lysyl-fluorescein (CLF) WB-UGT1A UGT1A WB-UGT1A1 UGT1A1 WB-UGT2B7 UGT2B7 7-Hydroxyquinoline (7-HQ) WB-UGT1A6 UGT1A6 3-[2-(N,N-Diethyl-N-methylammonium)ethyl ]-7-hydroxy-4-methylcoumarin (AHMC)3-[2-(N,N-Diethyl-N-methylammonium )ethyl]-7-methoxy-4-methylcoumarin (AMMC)3-Cyano-7-ethoxycoumarin (CEC)3-Cyano-7-hydroxycoumarin (CHC)