Beck Depression Inventory (BDI)
Diagnostic Interview Schedule (DIS) N = 31 Primary care patients who completed both the BDI and DIS, San Francisco, US [Does not give demographic information specific to this sub-group of patients] Prevalence of depression – 3/31 Depressive disorders Cut-off ≥ 10 - BDI Sensitivity = 100% Specificity = 75% Cut-off ≥ 16 - BDI
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Hamilton Depression Rating Scale (HDRS)
www.ncbi.nlm.nih.govHamilton Depression Rating Scale (HDRS) Hamilton Depression Rating Scale (HDRS) Study Identification tool Comparator/ caseness Population Results Community Stukenberg et al., 1990 Quality assessed: + HDRS DSM-III-R (SCID) N=177 community dwelling adults over 55 years, age
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www.ncbi.nlm.nih.gov• Select a basic method to model a sequence family – what are the states, what are the emitted symbols. • Using a training set – a set of known sequences in the family – estimate the parameters of the model: emission and transition probabilities.
Lecture 7 Protein-Protein Interaction
www.ncbi.nlm.nih.govthe DNA-binding domain (DB: blue circle) and one that contains an activation domain (AD: half blue circle), are co-transfected into an appropriate host strain. (C) If the fusion partners (yellow and red) interact, the DB and AD are brought into proximity and can activate transcription of reporter genes (here LacZ).
Lecture 10 : Whole genome sequencing and analysis
www.ncbi.nlm.nih.govPolymorphism (SNP): a variation is a single nucleotide in a genome • Typically we have two say alleles (here C and T) minor (less common) and major. • minor allele frequency - the ratio of chromosomes in the population carrying the less common variant to those with the more common variant • A second generation human
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Lecture 2 Pairwise sequence alignment.
www.ncbi.nlm.nih.govDiscovering sequence similarity by dot plots Given are two sequence lengths n and m respectively. Do they share a similarity and if so in which region? Dot-plot method: make n x m matrix with D and set D(i,j) = 1 if amino-acid (or nucleotide) position i in first sequence is the same (or similar as described later) as the amino-acid
Lecture 11 Phylogenetic trees
www.ncbi.nlm.nih.govVersion parsimony models: • Character states – Binary: states are 0 and 1 usually interpreted as presence or absence of an attribute (eg. character is a gene and can be
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