ホウ素中性子捕捉療法（BNCT）照射システム 開発ガイドラ …

1 BNCT 1.. 1 .. 1 .. 1 2.. 1 .. 1 BNCT .. 2 .. 4 3.. 4 .. 4 .. 5 .. 6 .. 7 .. 8 .. 11 .. 12 in vitro .. 15 in vivo .. 16 4.. 17 APPENDIX .. 20 APPENDIX 1 .. 20 IAEA-TECDOC-1223 Current status of neutron capture therapy (May 2001) .. 20 / .. 23 .. 25 IEC/TC 62/SC 62C Equipment for radiotherapy, nuclear medicine and radiation dosimetry .. 26 APPENDIX 2 .. 30 APPENDIX 3 .. 30 BNCT Boron neutron capture therapy BPA L-4-boronophenylalanine BNCT BSH Disodium ortho-mercaptoundecahydrododecaborate BNCT CBE Compound biological effectiveness DTL Drift tube linac 18F BPA [18F]

2 -L-4-borono-2-fluorophenylalanine F BPA GEANT4 Geometry and tracking 4 ICP-AES Inductively coupled plasma atomic emission spectrometry ICP-MS Inductively coupled plasma mass spectrometry KERMA Kinetic energy released in matter MCNP* A general Monte Carlo n-particle transport code MCNPX* Monte Carlo n-particle transport code system for multiparticle and high energy applications 150 MeV MCNP PET Positron emission tomography PGA Prompt gamma-ray analysis PHITS Particle and heavy ion transport code system PPM Parts per million 1 SI g/mL QA/QC Quality assurance / Quality control RFQ Radio frequency quadrupole 4 RBE Relative biological effectiveness SPECT Single photon emission computed tomography TCD50 Tumor control 50 assay TCD50 50% T/B ** Tumor / Blood ratio T/N ** Tumor / Normal tissue ratio N/B ** Normal tissue / Blood ratio *MCNP MCNPX MCNP6 ** 1 BNCT 1.

3 Boron Neutron Capture Therapy BNCT BNCT ( ) PMDA BNCT BNCT APPENDIX 3 [1]-[3] 2. BNCT 10 10B 2 7Li 2 BNCT BNCT KUR JRR-3 JRR-2 JRR-4 MuITR BNCT [1]-[4]

4 1990 IAEA-TECDOC-1223 KUR JRR-4 BPA PET BNCT 2011 JRR-4 2019 BNCT KUR BNCT BNCT BNCT BNCT BNCT BNCT BNCT BNCT BNCT 1 BNCT BNCT BNCT mA mA 3 MeV 30 MeV 180 C BNCT RFQ RFQ DTL MeV mA MeV 2mA d d,d d,t 1 2019 11 BNCT 1 BNCT 2019 11 MeV mA mA Be P: 30, N.

5 < 28 1 1 BNCT 1) BNCT 1) CICS Li P: , N: < 1 20 12 BNCT Be P: 8, N: < 6 5 <2 Li P: , N: < 1 15 NA Budker Institute 2) Li , N: < 1 10 2 Budker Institute Neutron Therapeutics Inc. ( ) 2) Li , N: < 1 30 30 4 DawonMedax ( ) 2) Be P: 10, N: < 8 8 Gi Medical Center SARAF ( ) 2) Li P<4, N: < 1 20 (?) 1-2 CNEA ( )2) Be P, d P: , N: < 6 30 <1 Legnaro INFN ( )2) Be P<4, N: < 2 30 NA 1) 2) Proc. 18th International Congress on Neutron Capture Therapy (ICNCT-18, 2018/11/06 Taipei) BNCT 2 2 BNCT D T 3.

6 BNCT 1 BNCT 3 BNCT 5 3 BNCT H29 BNCT WG H29 BNCT WG 7 4 4 No. BNCT * ** 1 (3) 2) 2 (2) 2) BNCT 1 30 1 1 2 6 3 (2) 1) 4 (2) 2) 5 (2) 3)

7 6 in vitro in vitro (2) 4) 7 in vivo in vivo (2) 5) * () ** ( ) 4 WG 1 1 BNCT BNCT 1-2 1 7 BNCT 2 BNCT T/B 1 BNCT 1)

8 BNCT 1 QA 1 2 8 3 1 2 1 2 1 2 3 BNCT 9 2 1) 2) 2 2)

9 1 BNCT 2 3 1 BNCT 2 10 1)

10 BNCT 1 2 3 4 1)