乳房 Breast （C50）

1 2021 9 1 . Breast C50 .. ICD-O-3 C50.. ICD-O-3 . 5 .. 8 .. 2019 60 10 . 35 50 . 5 . 2017 10 . 40 60 .. 2016 C50 7 . 1 4 1 45 4 1 24 . 2 .. Breast mammary gland . lobule . 15 25 mammary duct nipple .. nipple( ). nipple areola( ).. mammary gland . subcutaneous tissue skin . 20 . 20 .. ICD-O-3 2 . 4 6 .. ICD-O-3 .. ICD-O . 18 . E' ( . E ( . A . B ( ) . C ( .. D ( .. C' ( . ,NOS.. AB, AC .. CA . ,NOS.. 18 Paget .. 8500/3 6 . ICD-O-3 18 . ( ) . TNM.. 18 . Noninvasive carcinoma Ductal carcinoma in situ 8500/2. Lobular carcinoma in situ 8520/2.)))))

2 Encapsulated papillary carcinoma 8504/2. Paget Paget's disease, mammary, in situ 8540/2. Invasive carcinoma Invasive ductal carcinoma 8500/3. Tubule forming type 8500/31. Solid type 8500/32. Scirrhous type 8500/33. Other type 8500/39. Special types Invasive lobular carcinoma 8520/3. Tubular carcinoma 8211/3. Invasive cribriform carcinoma 8201/3. Mucinous carcinoma 8480/3. Medullary carcinoma 8510/3. Apocrine carcinoma 8401/3. Metaplastic carcinoma Squamous cell carcinoma 8070/3. Carcinoma with mesenchymal differentiation Spindle cell carcinoma 8572/3.

3 Carcinoma with osseous 8571/3. /cartilaginous differentiation Matrix-producing carcinoma 8575/3. Invasive micropapillary carcinoma 8507/3. Secretory carcinoma 8502/3. Adenoid cystic carcinoma 8200/3. Other Encapsulated papillary carcinoma with invasion 8504/3. Paget Paget's disease 8540/3. Phyllodes tumor (Cystosarcoma phyllodes), malignant 9020/3. Carcinosarcoma 8980/3. Stroma sarcoma 8935/3. hemangiosarcoma 9120/3. Lymphangiosarcoma 9170/3. TNM . TNM . 6 .. non-invasive Carcinoma in situ . microinvasion .. 1) UICC TNM 8.

4 T- 510 610 . / . T4 . / / . peu d'orange .. / / .. pT . Tis . Tis . Tis DCIS . Tis LCIS . Tis / .. T1 2cm . T1mi b T1a . T1b 1cm . T1c 1cm 2cm . T2 2cm 5cm . T3 5cm . T4 / C. T4a . T4b . T4c T4a T4b . T4d d b . C .. d .. T .. Tis . T1mi . T1a . T1. T1b . T1c . T2 . T3 .. T4a .. T4b . T4. T4c . T4d . N- 520 620 .. cN pN . cN .. LN LN . N . cN .. UICC TNM .. 8 .. cN0 . cN1 . cN2a . cN2. cN2b . cN3a .. cN3 cN3b / .. cN3c .. pN .. UICC TNM .. 8 .. pN0 . pN1mi 200 . pN1a 1 3 . pN1. pN1b . pN1c 1 3 . pN2a 4 9 . pN2. pN2b.

5 10 . pN3a 1 . pN3 1 1 . pN3b 4 . pN3c 1 .. M- 530 630 . CT/MRI . M0 . M1 . Stage- 500 600 . UICC TNM cStage Matrix . UICC TNM8 N0 N1 N2a,N2b N3a-N3c T0 A A C. Tis . T1mi, IA A A C. T1a-T1c T2 A B A C. T3 B A A C. T4a-T4d B B B C. M1 . UICC TNM pStage Matrix . UICC TNM8 N0 N1mi N1a-N1c N2a,N2b N3a-N3c T0 IB A A C. Tis . T1mi, IA IB A A C. T1a-T1c T2 A B B A C. T3 B A A A C. T4a-T4d B B B B C. M1 . 2) 580 680 . UICC TNM Matrix . UICC TNM 8. N0 N1,N2 N3a,N3b N3c . Tis 400 . 420 420 . T0 . 440 . 420 420 . T1 410 .. 440.

6 420 420 . T2 410 .. 440 . 420 420 . T3 410 .. 440 . T4 430 430 430 440 . M1 440 440 440 440 . TNM .. 1 X mammography MMG . X . 1 5 . 2 .. 3 MRI .. 4 X CT .. 5) (Fine needle aspiration cytology FNB).. 6 . core needle biopsy CNB ( ) . core needle biopsy .. 7 . CEA, CA15-3 . 8 .. ER estrogen receptor, PgR progesterone receptor .. Allred score J-score . HER2 human epidermal growth factor receptor-2; 2 . HER2 . ISH FISH CISH DISH . Ki67 . Ki67 Ki67 . Ki67 Ki67 . MIB-1 Ki67 MIB-1 Ki67 . MIB-1 index .. TNM .. 1 700 710 720.

7 (1) 700 . a . Tumorectomy; Tm .. partial mastectomy/lumpectomy; Bp . total mastectomy; Bt Mj Mn Bt+Mn+Mj .. microdochectomy; Md . skin sparing mastectomy; Bt(SSM).. Bt . nipple sparing mastectomy; Bt(NSM).. b . i) SN.. SN SN Im .. ii) Ax . I, II, III . Ax(I), Ax(II), AX(III) . 2 710 . Video-assisted surgery 2016 .. Sc LN Cw Tb .. tissue expander TE IMP LD TRAM. 3 730 .. 730 .. 2) 740 .. 3) 750 760 . (1) 750 .. AC DXR ADM CPA . EC EPI CPA. CEF100 CPA EPI 5-FU 5-FU . CMF CPA MTX 5-FU. TC DTX CPA. PTX 1 . nab-PTX nab.

8 DTX .. VNR . GEM .. 2 760 . TAM . TAM ZOL . TAM . ANA . LET . EXE .. LET .. CPA cyclophosphamide . MTX Methotrexate . 5-FU fluorouracil 5-FU. DXR(ADM) doxorubicin . EPI epirubicin . CPA cyclophosphamide . PTX paclitaxel . ACD Actinomycin D D . CPT-11 Irinotecan . GEM Gemcitabine . ADM doxorubicin . MIT Mitoxantrone . Capecitabine . VNL Vinorelbine . FT,TGF Tegafur . UFT Uracil/Tegafur . 5'DFUR Doxifluridine . MMC Mitomycin C C . MTX Methotrexate . L-PAM Melphalan . Trastuzumab . Pertuzumab . Lapatinib . Trastuzumab emtansine.

9 TAM tamoxifen citrate . TOR Toremifen . ANZ Anastrozole . EXE Exemestane . ZOL Goserelin . Leuprorelin . MPA Medroxyprogesteron . Fulvestrant . Ibrance .. HER-2 Human Epidermal Growth Factor Receptor 2 2. ER estrogen receptor . PgR progesterone receptor . SLN sentinel lymph node . ABC aspiration Breast cytology .. 1 21. 2 2016 . 3 UICCTNM 8 . 4 2018 5 18 . 5 1 2018 . 6 2 2018 . 7 7 2016 . 8 2016 . 9 2016 . 10 . 11 . 12 2016.