CARLO PAPPONE, MD, PhD, FACC - Af-Ablation

1 CARLO pappone , MD, PhD, FACC Biographical Sketch Dr. CARLO pappone is currently Director of the Department of Arrhythmology at the Hospital San Raffaele in Milan, Italy. He graduated, with honors, from the School of Medicine of Federico II Naples University in 1986 with the thesis: Effects of iloprost in the treatment of acute myocardial infarction . In 1986 he got his Medical Licensure with the score: 90/90 cum honors. In 1990 he achieved his Cardiology Specialty Degree with the thesis: Transcatheter radiofrequency ablation of post-infarction ventricular techycardias obtaining the score of 70/70 with honors. His electrophysiological training, 4 years long altogether, was partly spent at the University of Michigan, in Ann Arbor, Michigan, under the tutelage of the Chief Fred Morady, MD (July- September 1991) and at University of Oklahoma Health Sciences Center, Oklahoma City, OK, under the tutelage of the Chief Jackman, MD (July August 1992).

2 In 1995 he accomplished the PhD degree in Cardiovascular Pathophysiology, at the University "Tor Vergata", in Rome, with the thesis: Transcatheter radiofrequency ablation of atrial tachicardia: mapping techniques . On the clinical side Dr. pappone s interests and expertise are in the areas of Electrophysiology; Catheter ablation of cardiac arrhythmias, especially of Accessory Pathways and of atrial fibrillation; he contributed to the development and to the following clinical assessment of the nonfluoroscopic mapping; he pioneered the cardiac pacing in Italy, traditional and biventricular; he supported the spreading of the clinical assessment of a new system of Nonexcitatory cardiac contractility modulation aimed at the cure of the refractory heart failure in Europe, also acting as a coordinator. ample proof of his extensive experience in non-pharmacological treatment of cardiac arrhythmias, including the Atrial Fibrillation, is provided by the total number of procedures as first operator (over ) which makes him the most experienced electrophysiologist operator in the world ever.

3 For the first time in the history of interventional Cardiology and of general medicine he has performed a remote procedure 4000 miles away from the patient opening a new era. On May 18th 2006 he has carried out successfully the first transatlantic arrhythmia ablation procedure from Boston, while the patient was in Italy, miles away. In front of hundreds of spectators, during the annual Heart Rhythm Society Meeting, pappone performed an AF ablation procedure, by using a simple computer keyboard able to remotely control a magnetically guided ablation catheter. The importance of this event is that new frontiers have been crossed, as physicians can now carry out long-distance heart procedures in any part of the world. This is another significant scientific step forward in mankind welfare. This event can be considered as the beginning of a democratic medicine for everyone, as people living in underdeveloped countries can finally benefit from much more experienced centers by the remote ablative therapy.

4 As far as research is concerned, Dr. pappone 's primary interests include catheter-based treatment of cardiac arrhythmias and electrical therapies in patients with heart failure. Dr. pappone is recognized for his groundbreaking research on a new anatomic approach for atrial fibrillation ablation . He has been the primary investigator in clinical trials to evaluate non fluoroscopic cardiac mapping systems; to investigate the effects of a new cardiac contractility modulation electrical signal for treatment of heart failure; and to develop a novel catheter system for atrial fibrillation ablation . Transcatheter ablation of atrial fibrillation, this latter being an arrhythmias affecting up to 10% of the world population in certain age ranges, is today worldwide known as pappone approach as an acknowledgement of Dr. pappone s high and unrivaled expertise in this field. Dr. CARLO pappone has eventually settled a long and unresolved question arisen in the treatment of patients affected by Wolff-Parkinson-White syndrome, which may cause life-threatening arrhytmias.

5 His 2 randomized studies, published in the oldest and worldwide renown Medicine journal, the New England Journal of Medicine, demonstrate the validity of his approach to determine sudden death high-risk patients. Dr. pappone is the founder and Director of the Arrhythmology Academy at San Raffaele University-Hospital in Milan. Inaugurated in 2005, the Arrhythmology Academy promotes advances in interventional electrophysiology techniques ensuring these are translated as quickly as possible into healthcare benefits for society. The Academy upgrades theory and practice through interactive discussion and comments during live procedure demonstration performed by Dr. pappone , meetings, and training programs are attended annually by interventional electrophysiologists from all around the world. The Academy is accredited by the European Society of Cardiology (EBAC) Dr.

6 pappone has published 95 articles in international reviews and 22 articles in national review. Dr. pappone is Honorary Member of the most important world Cardiology and Electrophysiology societies, among which Heart Rhythm Society and ACC. Every year dr. pappone is invited to deliver Invited Lectures at the most important and attended American Cardiology and Electrophysiology Conferences He s also been Invited as visiting professor to deliver Cardiology Grand Round at the Virginia University and the Michigan University. He is also a member of the Editorial Board of the most prestigious American cardiology journals. Every year Dr. pappone is requested to review about 100 articles for American peer-reviewed Cardiology journals. In 2005 Dr. pappone has been elected Elite Reviewer of the Journal of the American College of Cardiology which is the official Journal of the American College of Cardiology His pioneering research has got the most prestigious cardiology journals to ask Dr.

7 pappone for editorial comments to many landmark papers published in peer-reviewed journals in the medicine field. For furtehr information about Dr. pappone and his teams s clinical and scientific activity, please visit the website , designed on purpose for both patients affected by atrial fibrillation and to medical specialists who want to update on the latest developments about AF ablation techniques and the current state-of-art in this field November, 2009 page Curriculum Vitae CARLO pappone , MD, PhD 1 1 CURRICULUM VITAE CARLO pappone , MD, PhD, FACC Date of Birth Dec. 05, 1961 Place of Birth Benevento, Italy Current Position Director, Department of Arrhythmology, Hospital San Raffaele, Milan, Italy Fields of Expertise Electrophysiology; Catheter ablation of cardiac arrhythmias; ablation of atrial fibrillation; Nonfluoroscopic mapping; Cardiac pacing; Biventricular pacing; Nonexcitatory cardiac contractility modulation.

8 Contact Information Hospital San Raffaele Via Olgettina 60, 20132 Milano, Italy Tel. +39 02 2643 7310 Fax + 39 02 26437326 E-mail: page Curriculum Vitae CARLO pappone , MD, PhD 2 2 Education MD Degree Oct. 29, 1986. School of Medicine, University of Naples Federico II. Thesis: Effects of iloprost in the treatment of acute myocardial infarction. Score: 110/110 with honors. Medical Licensure (Italy) 1986. Score: 90/90 cum honors. Cardiology Specialty Degree 1986-1990. University of Naples Federico II. Thesis: Transcatheter radiofrequency ablation of post-infarction ventricular tachycardias. Score: 70/70 with honors. Electrophysiology Training 1988-89. Interventional Electrophysiology, Hospital Policlinico San Matteo, Pavia. July September 1991. Division of Cardiology, Univ. of Michigan Medical Center, Ann Arbor, Michigan (Chief: F. Morady, MD) July August 1992. Division of Cardiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (Chief: Jackman, MD) PhD doctoral studies 1991-1995.

9 Doctorate in Cardiovascular Pathophysiology, University "Tor Vergata", Rome PhD degree Oct. 1995, with honors Thesis: Transcatheter radiofrequency ablation of atrial tachycardia: mapping techniques. page Curriculum Vitae CARLO pappone , MD, PhD 3 3 Clinical experience Total number of procedures performed as first operator Total EP studies: ~ ablation procedures: ~ PM implantation: ~ ICD implantation: ~ Biventricular PM: ~ Employment history Jan. 1989 Oct. 1995 Director, Electrophysiology Service, Universit degli Studi Federico II, Napoli Dec. 1995 Present Director, Department of Arrhythmology S. Raffaele University Hospital, Milan The Department is a 34 bed facility with 3 EP labs and a staff of 15 physicians and 18 nurses. 1996 2000 Responsible of the EP lab, Morgagni Heart Center, Catania 1997 2004 Responsible of the EP lab, Clinic Villa Maria Eleonora, Palermo 1998 2003 Responsible of the EP lab, S.

10 Rocco Clinic, Ome, Brescia page Curriculum Vitae CARLO pappone , MD, PhD 4 4 1998 - 2000 Responsible of the EP lab, Clinic, Villa Maria Eleonora, Lugo di Romagna, Ravenna Academic and Research Appointments 1995-1999 Associate Professor, Interventional Electrophysiology, Cardiology fellowship program, University of Naples "Federico II" 1999-2000 Director of the Course on Cardiovascular Diseases, S. Raffaele University Medical School, Milan, Italy March 15, 2002 Invited Visiting Professor, EP and Pacer Labs, German Heart Center, Munich, Germany Lecture: ablation of Atrial Fibrillation using Carto Live Demonstration March 25-26, 2002 Invited Visiting Professor, 5th PragueWorkshop on Catheter ablation , Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic Lecture: Catheter ablation of atrial fibrillation the Milan experience Live Demonstration page Curriculum Vitae CARLO pappone , MD, PhD 5 5 May 24, 2002 Invited Visiting Professor, 10th Anniversary Symposium of the Cardio- Thoracic Clinic, Restore Rhythm and Contractility , Bergamansheil, Klinikum der Ruhr,-Universit t Bochum.