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CHAPTER 1 INTRODUCTON Histopathology
Formalin is one of the commonly used fixative in all laboratories since it is cheap penetrates rapidly and does not over harden the tissues. • It preserves the proteins by forming crosslinkage with them and the tissue component. • It denatures the proteins. • Glycogen is partially preserved hence formalin is not a fixative choice
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documents.cap.org• Type of fixative, if other than buffered formalin • Treatment of the tissue that could potentially alter immunoreactivity (eg, decalcification) 7 • Status of controls: o Internal – normal epithelial cells positive or negative for ER and PgR
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