CHRISTIE M. SAYES, Ph.D. Department of Veterinary ...

1 CHRISTIE M. SAYES, Department of Veterinary Physiology & Pharmacology Texas A&M University College Station, TX 77843 979-862-2682 CURRENT POSITION Tenure-track Assistant Professor with the Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University o Executive Committee Member of the Intercollegiate Faculty of Toxicology o Member of the Faculty of Material Sciences & Engineering Adjunct Professor with the Department of Biomedical Engineering, Dwight Look College of Engineering, Texas A&M University Adjunct Professor with the Center for Environmental Genomic Medicine, Institute of Biosciences and Technology, Texas A&M Health Science Center EDUCATION & EXPERIENCE DuPont Haskell Laboratory for Health & Environmental Sciences (Dec 2005-Dec 2007) o Post-doctoral Fellow, Visiting Scientist Conducted pulmonary toxicity tests on rats exposed to nano- and fine-sized particles using instillation and inhalation methodologies Validated the in vitro responses of nanomaterials (carbon-based structures; metal colloidal and metal oxide systems) with in vivo test subjects (Sprague Dawley rats) Produced and characterized several nanoparticle systems relevant to toxicological evaluations Conducted aquatic toxicity studies on algae, daphnia, and fish using engineered nanomaterials Assisted in the preparation and launch of the DuPont-Environmental Defense collaborative Nano Risk Framework Rice University (May 2001-December 2005).

2 Doctorate of Philosophy in Chemistry o Candidate, (January 2003- December 2005) o Teaching Assistant, (May 2001- December 2003) Louisiana State University (August 1997- May 2001); Bachelor of Science in Chemistry o Technical Support Scientist, (December 2000-May 2001) RESEARCH FUNDING Current 1. NSF, Planning Visit: Multidisciplinary International Collaboration between Texas A&M University and Swansea University , (08/01/09-07/31/11) co-I. 2. NSF, BBSI: Vascular Bioengineering Summer Institute , (05/01/09-08/31/10) PI. 3. Texas A&M University Systems, Faculty Startup, Predicting toxicity of metal oxide nanoparticles: Developing quantitative structure-activity relationships and their generalizations for nanotoxicology research , (01/01/08-12/31/10) PI. Sayes 2 TEACHING EXPERIENCE Graduate and Undergraduate Courses Semester Course Title Name Credit Hour(s) Spring 2008 VTPP 676 Genetic and Molecular Tox Guest Lecturer Spring 2008 Tox Res Rotation J.

3 M. Berg Spring 2008 Tox Res Rotation Z. Berg Spring 2008 Tox Res Rotation N. Banerjee Fall 2008 Tox Res Rotation K. Scribner Fall 2008 Tox Res Rotation A. Romoser Fall 2008 VTPP 691 Res Hrs, Berg Fall 2008 VTPP 691 Res Hrs, N. Banerjee Spring 2009 VIBS 619 Food Toxicology Team Lecturer Spring 2009 VTPP 691 Res Hrs, Berg Spring 2009 VTPP 691 Res Hrs, N. Banerjee Spring 2009 VTPP 691 Res Hrs, A. Romoser Summer 2009 VTPP 485 Res Hrs, 8 UGs Fall 2009 VIBS 670 Basic Env. Toxicology Team Lecturer Fall 2009 VTPP 434 Physiology for Bioengineers I Team Lecturer Fall 2009 VTPP 691 Res Hrs, Berg Fall 2009 VTPP 691 Res Hrs, N. Banerjee Fall 2009 VTPP 691 Res Hrs, A. Romoser Students Trained Name Degree Institution Role Dates J. Michael Berg PhD TAMU-TOX Advisor 2008-present Nivedita Banerjee PhD TAMU-TOX Advisor 2008-present Amelia Romoser MS TAMU-TOX Advisor 2009-present Luis Ortega MS TAMU-MSEN Committee 2009 Dustin Ritter PhD TAMU-BMEN Committee 2009-present Matthew Kelly PhD TAMHSC-PHEO Committee 2009 Rema Zebda changed to medical school Advisor 2008-present Vanessa DeLaRosa transferred to UC Berkeley Advisor 2009-present Sayes 3 AWARDS Burroughs Wellcome Fund Investigators in Pathogenesis of Infectious Disease, Texas A&M University Nominee, 2009 Searle Scholars Program, Texas A&M University Representative, 2009 Empa, nanoEco Young Investigator Award, 2008 Society of Toxicology, Best Post-doctoral Publication Award, 2007 Society of Toxicology, Inhalation Specialty Section, Postdoctoral Award, 2006 1st Intn l Toxicology of Nanomaterials.

4 Biomedical Aspects Meeting, Young Investigator Award, 2005 Houston Livestock and Rodeo Endowed Scholarship, 2004 Harry B. Weiser Graduate Student Award for Research, 2004 Welch Fellowship Supplemental Award, 2001 ACADEMIC ACTIVITIES Developed TAMU course entitled, Basics in Nano: Experimental and Computational Research: A Collaborative Approach to Nanotechnology . Offered to senior undergraduates and all graduate students in biomedical sciences, engineering, mathematics, physics, and chemistry (2009-present). Director of an NSF-funded Bioengineering and Bioinformatics Summer Institute (BBSI), entitled, Vascular Bioengineering Summer Institute . Emphasize is placed on underrepresented minority student participates (2009-present). Counselor to the Society of Toxicology s nanotoxicology Specialty Section (2008-present) Member (co-Investigator) of a UK Environmental Nanoscience Initiative (UKENI) - Environmental Protection Agency (US EPA) research consortia addressing fate, behavior, bioavailability and effects of nanomaterials.

5 PROFESSIONAL MEMBERSHIPS Society for Toxicology ( nanotoxicology , Alternative Methods, & Inhalation Specialty Sections) American Institute of Chemical Engineers American Chemical Society Society of Environmental Toxicology and Chemistry RESEARCH PAPERS Sayes CM, Reed KL, Glover KP, Swain KA, Ostraat ML, Donner EA, Warheit DB; (2009) Changing the dose metric for inhalation toxicity studies: Short-term study in rats with engineered aerosolized amorphous silica nanoparticles. Inhalation Toxicology, in press. Sayes CM and Warheit DB; (2009) Characterization of nanomaterials for toxicity assessment . Nanomedicine and Nanobiotechnology, in press. Berg JM, Romoser A, Banerjee N, Zebda R, Sayes CM; (2009) The relationship between pH and Zeta potential of ~30 nm metal oxide nanoparticle suspensions relevant to in vitro toxicological evaluations . nanotoxicology , in press. Sayes 4 Warheit DB, Sayes CM, Reed KL; (2009) "Nanoscale and fine zinc oxide particles: Can in vitro assays accurately forecast lung hazards following inhalation exposures?

6 " Environmental Science & Technology, in press. Warheit DB, Reed KL, and Sayes CM; (2009) A role for surface reactivity in TiO2 and quartz-related nanoparticle pulmonary toxicity . nanotoxicology 3(03):181-187. Guo B, Zebda R, Drake SJ, Sayes CM; (2009) Synergistic effect of co-exposure to carbon black and Fe2O3 nanoparticles on oxidative stress in cultured lung epithelial cells . Particle and Fibre Toxicology 6:4. DB Warheit, CM Sayes, KL Reed, KA Swain; (2008) Health effects related to nanoparticle exposures: Environmental, health and safety considerations for assessing hazards and risks . Pharmacology & Therapeutics 120:35-42. Sayes CM, Reed KL, Abrams L, Subramoney S, Warheit DB; (2008) Validating in vitro nanoparticle toxicity measurements . Journal of Nanoparticle Research 11:421-431. Sayes CM, Marchione A, Reed KL, Warheit DB; (2007) Comparative pulmonary toxicity assessments of C60 water suspensions in rats: Few differences in fullerene toxicity in vivo in contrast to in vitro profiles.

7 Nano Letters 7(8):2399-2406. Sayes CM and Warheit DB; (2008) An in vitro investigation of the differential cytotoxic responses of human and rat lung epithelial cell lines using TiO2 nanoparticles . International Journal of Nanotechnology 5(1):15-29. Yu WW, Chang E, Falkner JC, Zhang J, Al-Somali AM, Sayes CM, Johns J, Drezek R, Colvin V; (2007) Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers . Journal of the American Chemical Society 129(10):2871-9. Warheit DB, Hoke R, Finlay C, Donner M, Reed KL, Sayes CM; (2007) Development of a base set of toxicity tests as a component of a nanoparticle risk management framework . Toxicology Letters 171:99 110. Sayes CM, Reed KL, Warheit DB; (2007) Assessing toxicity of fine and nanoparticles: Comparing in vitro measurements to in vivo pulmonary toxicity profiles.

8 Toxicological Sciences 97(1):163 180. Warheit DB, Webb TR, Reed KL, Sayes CM; (2007) Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Evidence for differential responses . Toxicology 230:90-104. Warheit DB, Webb TR, Colvin VL, Reed KL, Sayes CM; (2007) Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: Toxicity is not dependent upon particle size but on surface characteristics . Toxicological Sciences 95(1):270 280. Sayes 5Yu WW, Chang E, Sayes CM, Drezek R, Colvin VL; (2006) Aqueous dispersion of monodisperse magnetic iron oxide nanocrystals through phase transfer . Nanotechnology 17(17):4483-4487. Sayes CM, Wahi R, Kurian P, Liu Y, West JL, Ausman KD, Warheit DB, Colvin VL; (2006) Correlating nanoscale titania structure with toxicity: A cytotoxic and inflammatory response study with human dermal fibroblasts and human lung epithelial cells.

9 Toxicological Sciences 92(1):174-185. Warheit DB, Webb TR, Sayes CM, Colvin VL, Reed KL; (2006) Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: Toxicity is not dependant upon particle size and surface area . Toxicological Sciences 91(1):227-236. Sayes CM, Liang F, Hudson JL, Mendez J, Guo WH, Beach JM, Moore VC, Doyle CD, West JL, Billups WE, Ausman KD, Colvin VL; (2006) Functionalization density dependence of SWNT cytotoxicity in vitro . Toxicology Letters 161(2):135-142. Lyon DY, Fortner JD, Sayes CM, Colvin VL, Hughes JB; (2005) Bacterial cell association and antimicrobial activity of a C60 water suspension . Environmental Toxicology and Chemistry 24(11):2757-2762. Sayes CM, Gobin AM, Mendez J, West JL, Colvin VL; (2005) Nano-C60 cytotoxicity is due to lipid peroxidation . Biomaterials 27(5):7587-7595. Chen M, Falkner J, Guo WH, Zhang JY, Sayes CM, Colvin VL; Synthesis and self-organization of soluble monodisperse palladium nanoclusters.

10 Journal of Colloid and Interface Science 287(1): 146-151 (2005). Fortner JD, Lyon D, Sayes CM, Guo WH, Tao YJ, Ausman KD, Hughes JB, Colvin VL; (2005) C60 in water: nanocrystal formation and microbial response . Environmental Science and Technology 39(11):4307. Sayes CM, Fortner JD, Guo W, Lyon DY, Boyd AM, Ausman KD, Tao YJ, Sitharaman B, Wilson LJ, Hughes JB, West JL, Colvin VL; (2004) The differential cytotoxicity of water-soluble fullerenes . Nano Letters 4(10):1881. Hammer RP, Owens CV, Hwang SH, Sayes CM, Soper SA; (2002) Asymmetrical, water-soluble phthalocyanine dyes for covalent labeling of oligonucleotides . Bioconjugate Chemistry 13(6):1244-1252. Boyd JE, Briskman A, Sayes CM, Mittleman D, Colvin V; (2002) Terahertz vibrational modes of inverse micelles . Journal of Physical Chemistry B 106(24):6346-6353. Billodeaux DR, Owens CV, Sayes CM, Soper SA, Fronczek FR; (1999) Pseudosymmetry with Z '=4 in 1,3-propanesultone at 100 K.