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1 References .. OVA-IgE . 1 Sato E, Hirahara K, Wada Y, Yoshitomi T, Azuma T, Matsuoka K, Kubo S, .. Taya C, Yonekawa H, Karasuyama H, Shiraishi A. Chronic inflammation of the skin can be induced in IgE transgenic mice by means of a single s OVA-IgE . Tg(IgE-H01-4)Rin Tg IgE-kL01-4 Rin /Jcl . BALB/cA- challenge of multivalent antigen. J Allergy Clin Immunol. 2003; 111. IgE-H01-4 . BALB/cA- Tg Rin Tg Rin /Jcl . IgE-kL01-4 . 1 . 143-8. [PMID 12532110]. OVA-IgE . 2 Omata N, Ohshima Y, Yasutomi M, Yamada A, Karasuyama H, Mayumi s TNP-IgE.

2 M. Ovalbumin-specific IgE modulates ovalbumin-specific T-cell re- BALB/cA-Tg(IgE-Hb4)Rin Tg IgE-kLb4 Rin /Jcl .. IgE-Hb4 . Tg IgE-kLb4 . BALB/cA- /Jcl . Rin Tg Rin sponse after repetitive oral antigen administration. J Allergy Clin Immu- TNP-IgE . nol. 2005; 115 4 . 822-7. [PMID 15806005] . TNP-IgE . 1 Matsuoka K, Taya C, Kubo S, Toyama-Sorimachi N, Kitamura F, Ra C, Yo- nekawa H, Karasuyama H. Establishment of antigen-specific IgE trans- genic mice to study pathological and immunobiological roles of IgE in vivo. Int Immunol. 1999; 11 6.

3 987-94. [PMID 10360973]. 2 , , . - IgE . -.. 1999; 44 15 . 2523-8. [PMID 10586711]. 3 , . IgE - . -.. 2000; 192 10 . 1016-21. 4 , , . - IgE . -.. 2000; 26 8 . 43-47. 5 , , . d. IgE .. 2000; 7 8 . 61-9. 6 , , . IgE Fc RI .. 2000; 10 3 . 232-8. 7 , , , , , .. 2003; 35 5 . 21-4. 8 , , . IgE -IgE/Fc RI . -.. 2003; 16 4 . 308-15. 9 Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H, Iwamoto I. ergic Role of IgE in Th2 cell-mediated allergic airway Arch Allergy Immunol. 2003; 131 Suppl1 . 2-6. [PMID 12771541]. 10 Maezawa Y, Nakajima H, Seto Y, Suto A, Kumano K, Kubo S, Karasuya- ma H, Saito Y, Iwamoto I.

4 IgE-dependent enhancement of Th2 cell- g mediated allergic inflammation in the airways. Clin Exp Immunol. 2004; 135 1 . 12-8. [PMID 14678259]. 11 Mukai K, Matsuoka K, Taya C, Suzuki H, Yokozeki H, Nishioka K, Hiroka- wa K, Etori M, Yamashita M, Kubota T, Minegishi Y, Yonekawa H, Kara- suyama H. Basophils play a critical role in the development of IgE-medi- ated chronic allergic inflammation independently of T cells and mast cells. Immunity. 2005; 23 2 . 191-202. [PMID 16111637]. AD 153-8533 1-2-7. AD 564-0053 6-5. 063-0849 9 10 4-28.

5 983-0047 14-12.. s OVA-IgE BALB/cA- . IgE-H01-4 . Tg IgE-kL01-4 . Rin Tg s TNP-IgE BALB/cA- /Jcl . IgE-Hb4 . Tg IgE-kLb4 . Rin Tg Rin /Jcl . Rin . IgE. OVA . TNP 500 TNP-OVA. 10 -3 mm . 20. IgE g/ml . OVA-IgE TNP-IgE .. 15. 400. 2002 2008 . 10.. OVA. Tg hemi BALB/cAJcl 2008 11 N19 300. 5. 0 1 2 4 6 8 10 12 1 2 3 4 5 6 7. 0. BALB/c OVA-IgE TNP-IgE .. OVA-IgE TNP-IgE OVA TNP 1. IgE 4.. IgE BALB/c 1 . IgE OVA TNP TNP-IgE TNP-OVA . OVA . TNP-OVA 2 4 . 1.. IgE OVA-IgE. TNP-IgE IgE 39. IgE BSA. 38.. 2.. IgE 37 OVA OVA TNP-OVA . OVA-IgE TNP-IgE IgE.

6 36. 3. 35. T B . OVA-IgE TNP-IgE T B 0. 30 60 90. IgE .. 2. 5.. OVA-IgE OVA BSA 4 4 TNP-IgE .. OVA . IgE . 1.. OVA-IgE TNP-IgE OVA TNP-BSA . 2 . 500. 2.. TNP-IgE 1 3 . 10 -3 mm .. 3 20 30 2 . OVA-IgE OVA . 400.. 300. TNP-IgE . TNP-IgE TNP-OVA 0 4 8 12 16 20 24 28 32 36 40 44 48 52. Mice .. 2 30 5-10 2 1 . 4 3 3.. 5 1 2 3 TNP-IgE . 3 T A.