Comprehensive Placental Tissue Matrix & Amniotic

1 Comprehensive Placental TissueMatrix & AmnioticSolutions Advantages of Amniotic & Placental TissueMODULATE CORRECT Tissue RECONSTRUCTIONThe Placental Extracellular Matrix (ECM) modulates correct Tissue reconstruction rather than scar Tissue formation. This ECM includes growth factors, fibronectin, laminin, hyaluronic acid, proteoglycans, and other *REGULATES INFLAMMATION & FIBROSISAnti-inflammatory and anti-fibrotic proteins in Placental ECMs reduce inflammation, fibrous Tissue growth, and potential scar Tissue formation as they downregulate TGF-B, suppress pro-inflammatory cytokines, and inhibit MMPs and fibroblast , 3*NON-IMMUNOGENICP lacental tissues possess little risk of foreign body reaction in the patient, which can lead to fibrosis and graft failure.

2 They perform a similar role during pregnancy, preventing a response between baby and , 5*ANTI-MICROBIALP lacental Tissue contains components that help to create a healthy environment by potentially reducing bacteria counts in the wound. Its antibacterial effects have been demonstrated against a wide range of bacteria. *FOUNDATION FOR REGENERATIONP lacental ECMs contain Collagens I, III, IV, V, VI, VII, and fibrous proteins that provide a structural scaffold to support migration. Fibronectin, integrins, laminin, and hyaluronan also play a key role in proliferation, differentiation and adherence to the , 5* Data on file at Human Regenerative Technologies, Liu J, et al.

3 Update on Amniotic membrane transplantation. Expert Rev Ophthalmol., 2010;5(5), Dua HS, et al. The Amniotic membrane in ophthalmology. Survey of Ophthalmology, 2004;49(1) Hao Y, et al. Identification of antiangiogenic and anti-inflammatory proteins in human Amniotic membrane. Cornea. 2000;19 Kubo M, et al. Immunogenicity of human Amniotic membrane in experimental xenotransplantation. Invest Ophthalmol Vis Sci, 2001;42(7) Hori J, et al. Immunological characteristics of Amniotic epithelium. Cornea, 2006;25:S53-S58. *Statements are based on studies of amnion and/or Placental tissues generally and are not specific to VIAFLOW or actishield .

4 actishield & actishield CF Amniotic Barrier MembranesPRODUCT DESCRIPTION actishield and actishield CF Amniotic Barrier Membranes are biologic allografts derived from dehydrated human Amniotic Tissue . actishield and actishield CF membranes are sterilized post packaging. Two thicknesses available > Amnion only ( actishield CF) > Chorion based membrane ( actishield ) Ideal handling, both dry and wet* Adheres well without sutures* Easy to apply topically and internally* Creates no additional bulk at the site* 5 year shelf life at ambient temperatureVIAFLOW & VIAFLOW C Flowable Placental Tissue MatricesPRODUCT DESCRIPTIONVIAFLOW & VIAFLOW C Flowable Placental Tissue Matrices are unique, pre-mixed, Tissue Matrix allografts, processed from human Placental tissues.

5 This Tissue Matrix contains collagens, growth factors, and other key biologic components.* Two configurations available > Ambient temperature (VIAFLOW ) > Cryopreserved (VIAFLOW C) 5 year shelf life at ambient temperature (VIAFLOW ) 5 year shelf life at -40o C (VIAFLOW C) Flowable through a 23G needle Injectable to target defects quickly and precisely Easily mixable with autologous fluids**Data on file at Human Regenerative Technologies, InformationPart#DescriptionAM20-2X04 actishield Amniotic Barrier Membrane 2x4cm AM20-4X04 actishield Amniotic Barrier Membrane 4x4cmAM20-4X08 actishield Amniotic Barrier Membrane 4x8cmACTISHIELD Amniotic Barrier MembranePart#DescriptionAMAF-0005 VIAFLOW Flowable Placental Tissue Matrix Flowable Placental Tissue Matrix Flowable Placental Tissue Matrix Flowable Placental Tissue MatrixPart#DescriptionAMCF-0010 VIAFLOW C Cryopreserved Flowable Placental Tissue Matrix C Cryopreserved Flowable Placental Tissue MatrixPart#DescriptionAM45-2X04

6 actishield CF Amniotic Barrier Membrane 2x4cm AM45-4X04 actishield CF Amniotic Barrier Membrane 4x4cmAM45-4X08 actishield CF Amniotic Barrier Membrane 4x8cmACTISHIELD CF Amniotic Barrier Membrane and denote Trademarks and Registered Trademarks of Wright Medical Group or its affiliates. 2017 Wright Medical Group or its affiliates. All Rights Reserved. 012698D 22-Aug-20171023 Cherry Road Memphis, TN 38117 800 238 7117 901 867 9971 Kingston RoadStaines-upon-ThamesSurrey TW18 4 NLUnited Kingdom+44 (0)845 833 4435161 Rue Lavoisier38330 Montbonnot Saint MartinFrance+33 (0)4 76 61 35 00