共用基準範囲対応 CTCAE Grade定義 - jcog.jp

1 CTCAE Grade - jcog 2014 12 20 jcog 3 jcog jcog - 2 2011 6 25 75 jcog 2014 9 20 88 jcog jcog jcog - 2 2011 6 25 75 jcog 2014 9 20 88 jcog 2014 12 20 89 jcog 10007839 CD4 Grade 1 800 500 /mm3 Grade 2 500 200 /mm3 Grade 3 200 50 /mm3 Grade 4 50 /mm3 10024574 Grade 1 53 U/L Grade 2 106 U/L Grade 3 106 265 U/L Grade 4 265 U/L 10000636 Grade 1 37 sec Grade 2 sec Grade 3 sec Grade 4 10016596 Grade 1 180 135 mg/dL Grade 2 135 90 mg/dL Grade 3 90 45 mg/dL Grade 4 45 mg/dL 10019150 Grade 1 19 mg/dL Grade 2 Grade 3 Grade 4 10000486 jcog Grade 4 Grade 1 pH Grade 2 Grade 3 pH Grade 4 - 1 - 10001680 jcog Grade 4 Grade 1 pH Grade 2 Grade 3 pH Grade 4 10007613 T Grade 1 ng/mL Grade 2 Grade 3 ng/mL Grade 4 10007612 I CTCAE Grade 1.

2 I I Grade 1 ng/mL Grade 3 Grade 1 Grade 2 Grade 3 ng/mL Grade 4 - 2 - CTCAE M edDR A Code CTCAE SOC CTCAE Te r m CTCAE Te r m Grade 1 Grade 2 Grade 3 Grade 4 jcog 10000636 Activated partial thromboplastin time prolonged ULN ULN ULN; - jcog 37 sec 25-37 sec sec sec sec - 10007612 Cardiac troponin I increased , , - - I CTCAE Grade 1 , , I I Grade 1 ng/mL Grade 3 ng/mL - - ng/mL - 10007613 Cardiac troponin T increased T.

3 - - T T ng/mL ng/mL ng/mL - ng/mL - 10007839 CD4 lymphocytes decreased CD4 LLN-500 /mm3; 10e9 /L 500-200/mm3; 10e9 /L 200-50/mm3; 10e9 /L 50 /mm3; 10e9 /L CD4 CD4 800 /mm3 800 /mm3 800-500 /mm3 500-200 /mm3 200-50 /mm3 50 /mm3 - 3 - CTCAE M edDR A Code CTCAE SOC CTCAE Te r m CTCAE Te r m Grade 1 Grade 2 Grade 3 Grade 4 jcog 10016596 Fibrinogen decreased LLN 25% LLN 25- 50% LLN 50- 75% LLN 75% 50 mg/dL 180 mg/dL 180 mg/dL 180-135 mg/dL 135-90 mg/dL 90-45 mg/dL 45 mg/dL 10019150 Haptoglobin decreased LLN - - - 19 mg/dL 19 mg/dL 19 mg/dL - - - 10024574 Lipase increased

4 ULN ULN ULN ULN 53 U/L 13-53 U/L U/L U/L 106-265 U/L 265 U/L 10000486 Acidosis pH . - pH pH jcog Grade 4 - pH - 10001680 Alkalosis pH . - pH pH jcog Grade 4 - pH - 10022402 INR increased INR ULN; ULN; ULN; - INR - - 4.