醫學新知與專欄 第二型糖尿病 ... - doctor.org.tw

1 252 : GLP-1 ( -1 glucagon -like peptide-1 (incretin) (glucagon-like peptide 1 GLP-1) (distal ileum) (colon) GLP-1 ( cells) (insulin) ( cells) (glucagon) GLP-1 GLP-1 (gastric emptying) (satiety sensation) GLP-1 -4 (dipeptidyl peptidase 4 DPP-4))

2 T2DM (incretin action) DPP-4 (incretinmimetics) DPP-4 (DPP-4 inhibitor) (glucagon-like peptide 1 agonists, GLP-1 agonists) T2DM -1 : GLP-1 ( -1 glucagon -like peptide-1 253 glucagon-like peptide-1 agonists, GLP-1 agonists -4 dipeptidyl peptidase-4 inhibitors, DDP-4 inhibitors GLP-1 1 GLP-1 L GLP-1 GLP-1 T2DM JOURNAL OF KAOHSIUNG MEDICAL ASSOCIATION 2015.)

3 Vol. 23, GLP-1 GLP-1 GLP-1 T2DM GLP-1 6 T2DM GLP-1 GLP-1 T2DM exenatide Byetta , Bydureon , liraglutide Victoza , GLP-1 Exendin-4 Gila monster GLP-1 DDP-4 Exenatide exendin-4 metformin glitazone Exenatide Byetta 5 g 6 60 10 Bydureon 2 mg Exenatide HbA1C exenatide exenatide Liraglutide GLP-1

4 : GLP-1 ( -1 glucagon -like peptide-1 Liraglutide HbA1C exenatide exenatide exenatide GLP-1 2005 DPP-4 2006 HbaA1C GLP-1 HbaA1C HbaA1C GLP-1 T2DM GLP-1 GLP-1 T2DM T2DM 1.)

5 -incretin DDP-4 137-140.( )2. Henriksen JH, de Muckadell OB. Secretin, its discovery, andthe introduction of the hormone concept. Scand J Clin Lab Invest 2000; 60: AK. Mitra Assemi Betsy AC. Diabetes Mellitus. In: Koda-Kimble Mary Anne et al. Applied Therapeutics: The Clinical Use Of Drugs, 9th ed. 2009, Chap. Mellitus. In: Pharmacotherapy: A Pathophysiologic Approach, 8th ed. 2009, Chap. J Schen. A Review of gliptins in 2011. Pharmacother.

6 2012, 13(1):81-99. JOURNAL OF KAOHSIUNG MEDICAL ASSOCIATION 2015. vol. 23.